Evidence map›Paper›PMID 29162424›Full record

ArticleJournal of pharmaceutical sciences2018

Injectable Hydrogels for Localized Chemotherapy and Radiotherapy in Brain Tumors.

Pilar de la Puente, Nicole Fettig, Micah J Luderer, Abbey Jin, Shruti Shah, Barbara Muz, Vaishali Kapoor, Sreekrishna M Goddu, Noha Nabil Salama, Christina Tsien and 4 more

Abstract read
In one paragraph

Article in Journal of pharmaceutical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Review
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  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. A Big Prospect for Hydrogel Nano-System in Glioma.International journal of nanomedicine · 2024
    Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Microfluidic Chip Device forLangmuir : the ACS journal of surfaces and colloids · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Pilar de la PuenteDepartment of Radiation Oncology, Washington University in Saint Louis School of Medicine, St. Louis, Missouri 63110.
Nicole FettigRadiology and Biomedical Engineering Department, Preclinical PET/CT Imaging Facility, Washington University in Saint Louis School of Medicine, St. Louis, Missouri 63110.
Micah J LudererDepartment of Radiation Oncology, Washington University in Saint Louis School of Medicine, St. Louis, Missouri 63110.
Abbey JinDepartment of Radiation Oncology, Washington University in Saint Louis School of Medicine, St. Louis, Missouri 63110; Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, Missouri 63110.
Shruti ShahDepartment of Radiation Oncology, Washington University in Saint Louis School of Medicine, St. Louis, Missouri 63110.
Barbara MuzDepartment of Radiation Oncology, Washington University in Saint Louis School of Medicine, St. Louis, Missouri 63110.
Vaishali KapoorDepartment of Radiation Oncology, Washington University in Saint Louis School of Medicine, St. Louis, Missouri 63110.
Sreekrishna M GodduDepartment of Radiation Oncology, Washington University in Saint Louis School of Medicine, St. Louis, Missouri 63110.
Noha Nabil SalamaDepartment of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, Missouri 63110; Department of Pharmaceutics and Industrial Pharmacy, Cairo University Faculty of Pharmacy, Cairo, Egypt.
Christina TsienDepartment of Radiation Oncology, Washington University in Saint Louis School of Medicine, St. Louis, Missouri 63110; Siteman Cancer Center, Washington University in Saint Louis School of Medicine, St. Louis, Missouri 63110.
Dinesh ThotalaDepartment of Radiation Oncology, Washington University in Saint Louis School of Medicine, St. Louis, Missouri 63110; Siteman Cancer Center, Washington University in Saint Louis School of Medicine, St. Louis, Missouri 63110.
Kooresh ShoghiRadiology and Biomedical Engineering Department, Preclinical PET/CT Imaging Facility, Washington University in Saint Louis School of Medicine, St. Louis, Missouri 63110; Siteman Cancer Center, Washington University in Saint Louis School of Medicine, St. Louis, Missouri 63110.
Buck RogersDepartment of Radiation Oncology, Washington University in Saint Louis School of Medicine, St. Louis, Missouri 63110; Siteman Cancer Center, Washington University in Saint Louis School of Medicine, St. Louis, Missouri 63110.
Abdel Kareem AzabDepartment of Radiation Oncology, Washington University in Saint Louis School of Medicine, St. Louis, Missouri 63110; Siteman Cancer Center, Washington University in Saint Louis School of Medicine, St. Louis, Missouri 63110. Electronic address: kareem.azab@wustl.edu.

Funding

Project 2 - Radiation-Induced Treatment of Multiple Myeloma using NanoparticlesU54CA199092 · NCI · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2015 to 2019
$11.5M
NCI NIH HHS U54 CA199092
6 · The paper itself

Abstract

Overall survival of patients with newly diagnosed glioblastoma (GBM) remains dismal at 16 months with state-of-the-art treatment that includes surgical resection, radiation, and chemotherapy. GBM tumors are highly heterogeneous, and mechanisms for overcoming tumor resistance have not yet fully been elucidated. An injectable chitosan hydrogel capable of releasing chemotherapy (temozolomide [TMZ]) while retaining radioactive isotopes agents (iodine, [

Indexed as

AnimalsAntineoplastic AgentsBrain NeoplasmsCell Line, TumorCombined Modality TherapyDacarbazineDisease ProgressionFemaleGlioblastomaHumansHydrogelsInjectionsIodine RadioisotopesMaleMiceMice, NudeAntineoplastic AgentsDacarbazineHydrogelsIodine-131Iodine RadioisotopesTemozolomideglioblastomahydrogelsinjectablelocalized chemotherapylocalized radiotherapy

Identifiers

PMID29162424
PMCPMC6093750

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.