ArticleDevelopment and psychopathology2017
When inflammation and depression go together: The longitudinal effects of parent-child relationships.
Article in Development and psychopathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- The Link Between Positive and Negative Parenting Behaviors and Child Inflammation: A Systematic Review.Child psychiatry and human development · 2023Pooled it
- Interpersonal stress, epigenetic indices of inflammation, and depressive symptoms: Longitudinal associations from adolescence to young adulthood.Neurobiology of stress · 2026Article
- Parent-Adolescent Relationship Quality and Parenting Stress Across More Than Two Decades: The Mediating Role of Depressive Symptoms.Family process · 2025Article
- Racial discrimination predicts depressive symptoms throughout adolescence among Black youth.Developmental psychology · 2023Article
- School Disengagement Predicts Accelerated Aging among Black American Youth: Mediation by Psychological Maladjustment and Moderation by Supportive Parenting.International journal of environmental research and public health · 2022Article
- Childhood adversity predicts black young adults' DNA methylation-based accelerated aging: A dual pathway model.Development and psychopathology · 2022Article
- Childhood adversity is linked to adult health among African Americans via adolescent weight gain and effects are genetically moderated.Development and psychopathology · 2021Article
- Parenting Styles, Depressive Symptoms, and Problematic Online Game Use in Adolescents: A Developmental Cascades Model.Frontiers in public health · 2021Article
- Longitudinal changes of inflammatory biomarkers moderate the relationship between recent stressful life events and prospective symptoms of depression in a diverse sample of urban adolescents.Brain, behavior, and immunity · 2020Article
- Parent-youth conflict as a predictor of depression in adulthood: a 15-year follow-up of a community-based cohort.European child & adolescent psychiatry · 2020Article
- Depressive symptoms and immune transcriptional profiles in late adolescents.Brain, behavior, and immunity · 2019Article
- Biological embedding of neighborhood disadvantage and collective efficacy: Influences on chronic illness via accelerated cardiometabolic age.Development and psychopathology · 2018Article
- Childhood trauma, pubertal timing, and cardiovascular risk in adulthood.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2018Article
- MTHFR regulatory effects on methylation of CG05575921 in response to smoking: Effects are also discernable using MTHFR expression.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2018Article
- Psychological Stress During Childhood and Adolescence and Its Association With Inflammation Across the Lifespan: A Critical Review and Meta-Analysis.Psychological bulletinArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Parent-child relationships have long-term effects on health, particularly later inflammation and depression. We hypothesized that these effects would be mediated by later romantic partner relationships and elevated stressors in young adulthood, helping promote chronic, low grade, inflammation as well as depressive symptoms, and driving their covariation. It has been proposed recently that youth experiencing harsher parenting may also develop a stronger association between inflammation and depressive symptoms in adulthood and altered effects of stressors on outcomes. In the current investigation, we test these ideas using an 18-year longitudinal study of N = 413 African American youth that provides assessment of the parent-child relationship (at age 10), pro-inflammatory cytokine profile and depressive symptoms (at age 28), and potential mediators in early young adulthood (assessed at ages 21 and 24). As predicted, the effect of harsher parent-child relationships (age 10) on pro-inflammatory state and increased depressive symptoms at age 28 were fully mediated through young adult stress and romantic partner relationships. In addition, beyond these mediated effects, parent-child relationships at age 10 moderated the concurrent association between inflammation and depressive symptoms, as well as the prospective association between romantic partner relationships and inflammation, and resulted in substantially different patterns of indirect effects from young adult mediators to outcomes. The results support theorizing that the association of depression and inflammation in young adulthood is conditional on earlier parenting, and suggest incorporating this perspective into models predicting long-term health outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.