ArticleDevelopment and psychopathology2017
Early life stress, FK506 binding protein 5 gene (FKBP5) methylation, and inhibition-related prefrontal function: A prospective longitudinal study.
Article in Development and psychopathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Epigenetic mechanisms affected by stress during adolescence and the increased risk for depression later in life: a systematic review.Molecular psychiatry · 2026Pooled it
- Adverse Life Experiences and Brain Function: A Meta-Analysis of Functional Magnetic Resonance Imaging Findings.JAMA network open · 2023Pooled it
- A systematic review of childhood maltreatment and DNA methylation: candidate gene and epigenome-wide approaches.Translational psychiatry · 2021Pooled it
- DNA methylation and brain structure and function across the life course: A systematic review.Neuroscience and biobehavioral reviews · 2020Pooled it
- Epigenetics in persons living with HIV: trauma, coping, andEpigenomics · 2025Article
- From trauma to depression: structural, synaptic, epigenetic, and molecular pathways linking early stress to lifelong vulnerability.Frontiers in psychiatry · 2025Review
- Intermediate endophenotypes and epigenetic mechanisms of psychiatric disorders.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Early life stress modulates the genetic influence on brain structure and cognitive function in children.Heliyon · 2024Article
- Legacies of salient environmental experiences-insights from chemosensation.Chemical senses · 2024Article
- Associations between COVID-19-related family hardships/distress and children's Adverse Childhood Experiences during the pandemic: The Environmental influences on Child Health Outcomes (ECHO) program.Child abuse & neglect · 2023Observational
- A Stress Protein-Based Suicide Prediction Score and Relationship to Reported Early-Life Adversity and Recent Life Stress.The international journal of neuropsychopharmacology · 2023Article
- Genetic variants, neurocognitive outcomes, and functional neuroimaging in survivors of childhood acute lymphoblastic leukemia.JNCI cancer spectrum · 2023Article
- Epigenetic changes, a biomarker for non-accidental injury.Pediatric research · 2023Article
- Epigenetic differences in stress response gene FKBP5 among children with abusive vs accidental injuries.Pediatric research · 2023Article
- Age-related no-go P300 amplitudes are moderated by exposure to early-life stress.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2022Article
- Association Between Childhood Maltreatment,Frontiers in psychiatry · 2022Article
- Functional imaging correlates of childhood trauma: A qualitative review of past research and emerging trends.Pharmacology, biochemistry, and behavior · 2021Review
- Promoting brain health through physical activity among adults exposed to early life adversity: Potential mechanisms and theoretical framework.Neuroscience and biobehavioral reviews · 2021Review
- Neural contributors to trauma resilience: a review of longitudinal neuroimaging studies.Translational psychiatry · 2021Review
- The impact of child abuse on the neurobiology of self-processing in depressed adolescents.Neurobiology of stress · 2021Article
Corrections and comments
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Authors and funding
8 authors.
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Abstract
Individuals who have experienced high levels of childhood stress are at increased risk for a wide range of behavioral problems that persist into adulthood, yet the neurobiological and molecular mechanisms underlying these associations remain poorly understood. Many of the difficulties observed in stress-exposed children involve problems with learning and inhibitory control. This experiment was designed to test individuals' ability to learn to inhibit responding during a laboratory task. To do so, we measured stress exposure among a community sample of school-aged children, and then followed these children for a decade. Those from the highest and lowest quintiles of childhood stress exposure were invited to return to our laboratory as young adults. At that time, we reassessed their life stress exposure, acquired functional magnetic resonance imaging data during an inhibitory control task, and assayed these individuals' levels of methylation in the FK506 binding protein 5 (FKBP5) gene. We found that individuals who experienced high levels of stress in childhood showed less differentiation in the dorsolateral prefrontal cortex between error and correct trials during inhibition. This effect was associated only with childhood stress exposure and not by current levels of stress in adulthood. In addition, FKBP5 methylation mediated the association between early life stress and inhibition-related prefrontal activity. These findings are discussed in terms of using multiple levels of analyses to understand the ways in which adversity in early development may affect adult behavioral adaptation.
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