ArticleDevelopment and psychopathology2017
Altered ventral striatal-medial prefrontal cortex resting-state connectivity mediates adolescent social problems after early institutional care.
Article in Development and psychopathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Adverse childhood experiences and resting state functional connectivity of the triple brain network: a meta-analysis.European archives of psychiatry and clinical neuroscience · 2026Pooled it
- Early life experiences, the neural epigenome and affective disorder risk.Nature reviews. Neuroscience · 2026Review
- A protocol for the Teen Bugs study: An integrative, multi-omics approach to understanding the role of the gut microbiome and mesocorticolimbic system in adolescent mental health following early adverse caregiving.Brain, behavior, & immunity - health · 2026Article
- Sex-specific associations of childhood adversity with frontostriatal network organization and anhedonia in young adulthood.bioRxiv : the preprint server for biology · 2026Article
- Functional connectivity of youth in family-like residential care in Japan: Impact of reactive attachment disorder and disinhibited social engagement disorder symptoms.Neuroimage. Reports · 2026Article
- Prefrontal cortex development and its implications in mental illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Patterns of brain-wide associations reflect socioeconomics.bioRxiv : the preprint server for biology · 2025Article
- Functional Connectivity of the Nucleus Accumbens across Variants of Callous-Unemotional Traits: A Resting-State fMRI Study in Children and Adolescents.Research on child and adolescent psychopathology · 2024Article
- Childhood adversity predicts striatal functional connectivity gradient changes after acute stress.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- The Added Value of Crosstalk Between Developmental Circuit Neuroscience and Clinical Practice to Inform the Treatment of Adolescent Anxiety.Biological psychiatry global open science · 2023Review
- Aberrant resting-state functional connectivity associated with childhood trauma among juvenile offenders.NeuroImage. Clinical · 2023Article
- Chronic psychosocial stress and experimental pubertal delay affect socioemotional behavior and amygdala functional connectivity in adolescent female rhesus macaques.Psychoneuroendocrinology · 2021Article
- Early Life Stress and Risks for Opioid Misuse: Review of Data Supporting Neurobiological Underpinnings.Journal of personalized medicine · 2021Review
- Social experience calibrates neural sensitivity to social feedback during adolescence: A functional connectivity approach.Developmental cognitive neuroscience · 2021Article
- A Narrative Review of Methodological Considerations in Magnetic Resonance Imaging of Offspring Brain Development and the Influence of Parenting.Frontiers in human neuroscience · 2021Review
- Impact of Early Life Stress on Reward Circuit Function and Regulation.Frontiers in psychiatry · 2021Review
- Defining Immediate Effects of Sensitive Periods on Infant Neurobehavioral Function.Current opinion in behavioral sciences · 2020Article
- Brain connectivity and socioeconomic status at birth and externalizing symptoms at age 2 years.Developmental cognitive neuroscience · 2020Article
- Adolescent gender differences in neural reactivity to a friend's positive affect and real-world positive experiences in social contexts.Developmental cognitive neuroscience · 2020Article
- The influence of relationship closeness on default-mode network connectivity during social interactions.Social cognitive and affective neuroscience · 2020Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
Abstract
Early caregiving adversity is associated with increased risk for social difficulties. The ventral striatum and associated corticostriatal circuitry, which have demonstrated vulnerability to early exposures to adversity, are implicated in many aspects of social behavior, including social play, aggression, and valuation of social stimuli across development. Here, we used resting-state functional magnetic resonance imaging to assess the degree to which early caregiving adversity was associated with altered coritocostriatal resting connectivity in previously institutionalized youth (n = 41) relative to youth who were raised with their biological families from birth (n = 47), and the degree to which this connectivity was associated with parent-reported social problems. Using a seed-based approach, we observed increased positive coupling between the ventral striatum and anterior regions of medial prefrontal cortex (mPFC) in previously institutionalized youth. Stronger ventral striatum-mPFC coupling was associated with parent reports of social problems. A moderated-mediation analysis showed that ventral striatal-mPFC connectivity mediated group differences in social problems, and more so with increasing age. These findings show that early institutional care is associated with differences in resting-state connectivity between the ventral striatum and the mPFC, and this connectivity seems to play an increasingly important role in social behaviors as youth enter adolescence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.