ArticleDevelopment and psychopathology2017
From child maltreatment to emerging adult problem drinking: Identification of a multilevel internalizing pathway among African American youth.
Article in Development and psychopathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Targets for intervention to prevent substance use in young people exposed to childhood adversity: A systematic review.PloS one · 2021Pooled it
- Systematic Review of Polygenic Gene-Environment Interaction in Tobacco, Alcohol, and Cannabis Use.Behavior genetics · 2019Pooled it
- Patterns of childhood maltreatment and maternal substance use disorder on the development of emerging adult offspring substance use.Developmental psychology · 2025Article
- Does Executive Functioning Moderate the Association Between Psychopathic Traits and Antisocial Behavior in Youth?Research on child and adolescent psychopathology · 2025Article
- The relative effects of parental alcohol use disorder and maltreatment on offspring alcohol use: Unique pathways of risk.Development and psychopathology · 2024Article
- Associations between early childhood adversity and behavioral, substance use, and academic outcomes in childhood through adolescence in a U.S. longitudinal cohort.Drug and alcohol dependence · 2023Article
- An Exploration of Practitioners' Perceptions and Beliefs About Trauma-Informed Youth Drug Prevention Programs: a Qualitative Study.Prevention science : the official journal of the Society for Prevention Research · 2022Article
- Early life stress and substance use disorders: The critical role of adolescent substance use.Pharmacology, biochemistry, and behavior · 2022Review
- Gender, Maltreatment and Psychiatric Symptoms among Adolescents in Outpatient Substance Abuse Treatment.Child & adolescent social work journal : C & A · 2020Article
- Article
- The Devastating Clinical Consequences of Child Abuse and Neglect: Increased Disease Vulnerability and Poor Treatment Response in Mood Disorders.The American journal of psychiatry · 2020Review
- Child maltreatment and the development of substance use and disorder.Neurobiology of stress · 2019Review
- Positive metacognitions about alcohol mediate the relationship betweenNeuropsychiatric disease and treatment · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
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Abstract
The present study tested the role of FKBP5 binding protein 5 (FKBP5) genetic variation in an internalizing pathway from child maltreatment to emerging adult problem drinking among a sample of African American youth (N = 280) followed prospectively from ages 11 to 20. Specifically, whether childhood internalizing symptoms and emerging adult tension reduction alcohol expectancies sequentially mediate the effect of child maltreatment on emerging adult problem drinking and whether FKBP5 moderates these associations were investigated. The results indicate that individuals with at least one copy of the FKBP5 CATT haplotype (minor alleles) are more vulnerable to traversing the hypothesized internalizing pathway of risk than individuals without this genotypic profile. Taken together our findings highlight the importance of FKBP5 genetic variation in the context of early adversity; support the role of two prospective sequential mediators of an internalizing pathway to problematic drinking, namely, childhood internalizing symptoms and emerging adult tension reduction alcohol expectancies; and identify a subgroup of maltreated children most susceptible to progressing along this less common pathway of risk.
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