Evidence map›Paper›PMID 29162177›Full record

ArticleDevelopment and psychopathology2017

Using an adoption-biological family design to examine associations between maternal trauma, maternal depressive symptoms, and child internalizing and externalizing behaviors.

Aleksandria Perez Grabow, Atika Khurana, Misaki N Natsuaki, Jenae M Neiderhiser, Gordon T Harold, Daniel S Shaw, Jody M Ganiban, David Reiss, Leslie D Leve

Open access · greenAbstract read
In one paragraph

Article in Development and psychopathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Research Review: A review of the past decade of family and genomic studies on adolescent mental health.Journal of child psychology and psychiatry, and allied disciplines · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Parenting in the Context of the Child: Genetic and Social Processes.Monographs of the Society for Research in Child Development · 2022
    Article
  9. Article
  10. The Meaning of "Cause" in Genetics.Cold Spring Harbor perspectives in medicine · 2021
    Article
  11. The Early Growth and Development Study: A Dual-Family Adoption Study from Birth Through Adolescence.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Aleksandria Perez GrabowUniversity of Oregon.
Atika KhuranaUniversity of Oregon.
Misaki N NatsuakiUniversity of California,Riverside.
Jenae M NeiderhiserPennsylvania State University.
Gordon T HaroldUniversity of Sussex.
Daniel S ShawUniversity of Pittsburgh.
Jody M GanibanGeorge Washington University.
David ReissYale Child Study Center.
Leslie D LeveUniversity of Oregon.
George Washington University · USPennsylvania State University · USUniversity of California, Riverside · USUniversity of Pittsburgh · USUniversity of Sussex · GB

Funding

The Early Growth and Development Study Pediatric CohortUH3OD023389 · OD · UNIVERSITY OF OREGON · PI Jody M. Ganiban, Leslie Diane Leve · 2018 to 2026
$16.6M
The Early Growth and Development Study: Family Process, Genes and School EntryR01HD042608 · NICHD · OREGON SOCIAL LEARNING CENTER, INC. · PI CAPALDI, DEBORAH M. · 2002 to 2011
$14.9M
Translational Drug Abuse Prevention CenterP50DA035763 · NIDA · OREGON SOCIAL LEARNING CENTER, INC. · PI CHAMBERLAIN, PATRICIA, FISHER, PHILIP A · 2013 to 2017
$9.5M
The Early Growth and Development Study Pediatric CohortUG3OD023389 · OD · UNIVERSITY OF OREGON · PI GANIBAN, JODY M., LEVE, LESLIE DIANE · 2016 to 2024
$7.5M
Genes, Prenatal Drug Exposure, and the Postnatal Environment: An Adoption StudyR01DA020585 · NIDA · PENNSYLVANIA STATE UNIVERSITY, THE · PI NEIDERHISER, JENAE M. · 2007 to 2011
$5.9M
Gene-Environment Interplay and Development of Psychiatric Symptoms in ChildrenR01MH092118 · NIMH · PENNSYLVANIA STATE UNIVERSITY, THE · PI LEVE, LESLIE DIANE, NEIDERHISER, JENAE M. · 2010 to 2014
$3.1M
Siblings Reared Apart: A Naturalistic Cross-Fostering Study of Young ChildrenR01DA035062 · NIDA · UNIVERSITY OF OREGON · PI LEVE, LESLIE DIANE · 2013 to 2016
$2.7M
Family and Peer Processes and G-E Interplay in Middle School: An Adoption StudyR56HD042608 · NICHD · UNIVERSITY OF OREGON · PI LEVE, LESLIE DIANE · 2014 to 2015
$700k
NICHD NIH HHS R01 HD042608NICHD NIH HHS R56 HD042608NIDA NIH HHS P50 DA035763NIDA NIH HHS R01 DA020585NIDA NIH HHS R01 DA035062NIH HHS UG3 OD023389NIH HHS UH3 OD023389NIMH NIH HHS R01 MH092118
6 · The paper itself

Abstract

Maternal trauma is a complex risk factor that has been linked to adverse child outcomes, yet the mechanisms underlying this association are not well understood. This study, which included adoptive and biological families, examined the heritable and environmental mechanisms by which maternal trauma and associated depressive symptoms are linked to child internalizing and externalizing behaviors. Path analyses were used to analyze data from 541 adoptive mother-adopted child (AM-AC) dyads and 126 biological mother-biological child (BM-BC) dyads; the two family types were linked through the same biological mother. Rearing mother's trauma was associated with child internalizing and externalizing behaviors in AM-AC and BM-BC dyads, and this association was mediated by rearing mothers' depressive symptoms, with the exception of biological child externalizing behavior, for which biological mother trauma had a direct influence only. Significant associations between maternal trauma and child behavior in dyads that share only environment (i.e., AM-AC dyads) suggest an environmental mechanism of influence for maternal trauma. Significant associations were also observed between maternal depressive symptoms and child internalizing and externalizing behavior in dyads that were only genetically related, with no shared environment (i.e., BM-AC dyads), suggesting a heritable pathway of influence via maternal depressive symptoms.

Indexed as

Mother-Child RelationsAdoptionAdultChildChild Behavior DisordersChild of Impaired ParentsChild, PreschoolDepressionFemaleHumansInfantMaleMothersRisk FactorsYoung Adult

Identifiers

PMID29162177
PMCPMC5726295
OpenAlexW2629178608

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.