ArticleDevelopment and psychopathology2017
Immune and neuroendocrine correlates of temperament in infancy.
Article in Development and psychopathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Factors Affecting the Applicability of Infrared Thermography as a Measure of Temperament in Cattle.Veterinary sciences · 2025Article
- A preliminary investigation of epigenome-wide DNA methylation and temperament during infancy.Developmental psychobiology · 2024Article
- The Association between Glucose 6-Phosphate Dehydrogenase Deficiency and Attention Deficit/Hyperactivity Disorder.Nutrients · 2023Article
- Patients with vitiligo have a distinct affective temperament profile: A cross-sectional study using Temperament Evaluation of Memphis, Paris, and San Diego Auto-Questionnaire.Skin health and disease · 2023Article
- Maternal Immune Activation Hypotheses for Human Neurodevelopment: Some Outstanding Questions.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Review
- Article
- Early Sensory and Temperament Features in Infants Born to Mothers With Asthma: A Cross-Sectional Study.Frontiers in psychology · 2021Article
- Early childhood risk exposures and inflammation in early adolescence.Brain, behavior, and immunity · 2020Article
- The role of anxious temperament in patients with allergic rhinitis.Saudi medical journal · 2019Article
- Cytokine Research in Depression: Principles, Challenges, and Open Questions.Frontiers in psychiatry · 2019Review
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Authors and funding
11 authors.
Funding
Abstract
There is now a clear focus on incorporating, and integrating, multiple levels of analysis in developmental science. The current study adds to research in this area by including markers of the immune and neuroendocrine systems in a longitudinal study of temperament in infants. Observational and parent-reported ratings of infant temperament, serum markers of the innate immune system, and cortisol reactivity from repeated salivary collections were examined in a sample of 123 infants who were assessed at 6 months and again when they were, on average, 17 months old. Blood from venipuncture was collected for analyses of nine select innate immune cytokines; salivary cortisol collected prior to and 15 min and 30 min following a physical exam including blood draw was used as an index of neuroendocrine functioning. Analyses indicated fairly minimal significant associations between biological markers and temperament at 6 months. However, by 17 months of age, we found reliable and nonoverlapping associations between observed fearful temperament and biological markers of the immune and neuroendocrine systems. The findings provide some of the earliest evidence of robust biological correlates of fear behavior with the immune system, and identify possible immune and neuroendocrine mechanisms for understanding the origins of behavioral development.
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