Evidence map›Paper›PMID 29162132›Full record

Trial reportTrials2017

Comparison of the effect of high versus low mean arterial pressure levels on clinical outcomes and complications in elderly patients during non-cardiothoracic surgery under general anesthesia: study protocol for a randomized controlled trial.

Anmin Hu, Yan Qiu, Peng Zhang, Bailong Hu, Yali Yang, Shutao Li, Rui Zhao, Zhongjun Zhang, Yaoxian Zhang, Zihao Zheng and 3 more

Registry-linked trialOpen access · goldAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Trials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02857153 (Comparsion of the Effect of High Versus Low Mean Arterial Pressure), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 73% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02857153 naunknown statusnot on this map

Comparsion of the Effect of High Versus Low Mean Arterial Pressure (MAP) Levels on Clinical Outcomes in Elderly Patients During Noncardiothoracic Surgery Under General Anesthesia

TypeinterventionalSponsorHu AnminRan2016 to 2017Enrolled322ConditionsAging, Surgery, Blood Pressure, AnesthesiaArmsUrapidil, Phenylephrine, Low-level MAP, High-level MAP
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

Anmin HuDepartment of Anesthesiology, Shenzhen People's Hospital, Shenzhen, 518001, China.
Yan QiuDepartment of Anesthesiology and Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, 610000, China.
Peng ZhangDepartment of Anesthesiology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, 610072, China.
Bailong HuDepartment of Anesthesiology, Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, China.
Yali YangDepartment of Anesthesiology, Henan Provincial People's Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Shutao LiDepartment of Anesthesiology, Taihe Hospital of Hubei University of Medicine, Shiyan, Hubei, 442000, People's Republic of China.
Rui ZhaoDepartment of Anesthesiology, The Third Affiliated Hospital of Kunming Medical University, Kunming, 650106, China.
Zhongjun ZhangDepartment of Anesthesiology, Shenzhen People's Hospital, Shenzhen, 518001, China. luckydoczhang@163.com.
Yaoxian ZhangDepartment of Anesthesiology, Shenzhen People's Hospital, Shenzhen, 518001, China.
Zihao ZhengDepartment of Anesthesiology, Shenzhen People's Hospital, Shenzhen, 518001, China.
Chen QiuClinical Medical Research Center, The Second Clinical Medicine College, Jinan University, Shenzhen, 518001, China.
Furong LiClinical Medical Research Center, The Second Clinical Medicine College, Jinan University, Shenzhen, 518001, China.
Xiaolei GongClinical Medical Research Center, The Second Clinical Medicine College, Jinan University, Shenzhen, 518001, China.
Jinan University · CNShenzhen Blood Center · CNGuiyang Medical University · CNHubei University of Medicine · CNKunming Medical University · CNSichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital · CNSichuan University · CNZhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntraoperative blood pressure (BP) is a concern in daily clinic anesthesia and contributes to the differences in clinical outcome. We conducted a randomized controlled trial (RCT) to compare the effect of high vs. low mean arterial pressure (MAP) levels on clinical outcomes and complications in elderly patients under general anesthesia (GA).

methodsIn this multicenter, randomized, parallel-controlled, open-label, assessor-blinded clinical trial, 322 patients aged more than 65 years will be randomized for a low-level MAP (60-70 mmHg) or high-level MAP (90-100 mmHg) during non-cardiothoracic surgery under GA. The primary outcome will be the incidence of postoperative delirium. The secondary outcomes will include the delirium duration days, intraoperative urine volume, intraoperative blood loss, specific postoperative complications, and all-cause 28-day mortality. DISCUSSION: Results of this trial will help clarify whether BP management is beneficial for elderly patients under GA and will make clear whether the effect of high-level MAP can reduce the postoperative complication compared to low-level MAP.

trial registrationClinicalTrials.gov, NCT02857153 . Registered on 15 July 2016.

Indexed as

Anesthesia, GeneralArterial PressureSurgical Procedures, OperativeAgedBlood Loss, SurgicalCause of DeathChinaClinical ProtocolsDeliriumFemaleHumansMaleMonitoring, IntraoperativeResearch DesignRisk FactorsTime FactorsElderly patientsGeneral anesthesiaMean arterial pressurePostoperative complication

Identifiers

PMID29162132
PMCPMC5698923
OpenAlexW2769306621

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.