Evidence map›Paper›PMID 29162085›Full record

ArticleBMC urology2017

Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea: results from a cross-sectional, population-based study.

Kyu-Sung Lee, Tag Keun Yoo, Limin Liao, Jianye Wang, Yao-Chi Chuang, Shih-Ping Liu, Romeo Chu, Budiwan Sumarsono

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in BMC urology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02618421 (A Cross-sectional Population Representative Internet Survey to Estimate Prevalence of Lower Urinary Tract Symptoms), which is not on this map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02618421 completednot on this map

A Cross-sectional Population Representative Internet Survey to Estimate Prevalence of Lower Urinary Tract Symptoms (LUTS) in China, Taiwan and South Korea

TypeobservationalSponsorAstellas Pharma Singapore Pte. Ltd.Ran2015 to 2015Enrolled8,284ConditionsLower Urinary Tract Symptoms
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Health-related quality of life among Chinese primary care patients with different lower urinary tract symptoms: a latent class analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021
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  12. Prevalence and impact on daily life of lower urinary tract symptoms in Japan: Results of the 2023 Japan Community Health Survey (JaCS 2023).International journal of urology : official journal of the Japanese Urological Association · 2024
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  20. The impact of overactive bladder on health-related quality of life in Korea: based on the results of a Korean Community Health Survey.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Kyu-Sung LeeDepartment of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Tag Keun YooDepartment of Urology, Nowon Eulji Medical Center, Eulji University School of Medicine, 68, Hangeulbiseok-ro, Nowon-gu, Seoul, Korea. ytk5202@eulji.ac.kr.
Limin LiaoDepartment of Urology, China Rehabilitation Research Center, Capital Medical University, Beijing, China.
Jianye WangDepartment of Urology, Beijing Hospital, Beijing, China.
Yao-Chi ChuangDepartment of Urology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Shih-Ping LiuDepartment of Urology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
Romeo ChuAstellas Pharma Singapore Pte. Ltd., Singapore, Singapore.
Budiwan SumarsonoAstellas Pharma Singapore Pte. Ltd., Singapore, Singapore.
Beijing Hospital · CNChang Gung University · TWChina Rehabilitation Research Center · CNEulji University · KRNational Taiwan University Hospital · TWSamsung Medical Center · KR

Funding

Astellas Pharma Singapore Pte., Ltd. n/a
6 · The paper itself

Abstract

backgroundLower urinary tract symptoms (LUTS) and overactive bladder (OAB) symptoms have a substantial effect on quality of life (QoL). We report QoL and mental health results from a LUTS prevalence study in three Asian countries.

methodsA cross-sectional, population-representative, internet-based study among individuals aged ≥40 years in China, Taiwan and South Korea. Instruments included: Overactive Bladder Symptom Score (OABSS); International Prostate Symptom Score (IPSS); other International Continence Society (ICS) symptom questions; health-related QoL 12-item short-form (HRQoL-SF12v2); Work Limitations Questionnaire (WLQ); Hospital Anxiety and Depression Scale (HADS). Presence of LUTS was determined according to ICS criteria, with three symptom groups (storage, voiding and post-micturition). Post-stratification weighting matched the age and sex population distribution per country. Initial data analyses were based on descriptive statistics. Significance testing undertaken post hoc included: independent-samples t-test (differences in HRQoL between sexes and between individuals with/without LUTS; relationship between HRQoL score and OABSS; differences in HADS anxiety and depression scores between individuals with/without LUTS; association between HADS anxiety/depression scores and OABSS), chi-square test (association between LUTS prevalence and workplace productivity) and analysis of variance (differences in HRQoL score and in HADS anxiety/depression scores between individuals with different symptom groups, association between HADS anxiety/depression scores and IPSS).

resultsIn total, 8284 participants were included. HRQoL scores were significantly worse (p < 0.001) among individuals with versus without LUTS (ICS criteria): mean physical health domain scores were 61.1 (standard deviation [SD], 20.1) and 76.7 (17.0), respectively; corresponding mental health domain scores were 34.8 (12.7) and 43.7 (10.7). Workplace productivity was best among individuals without LUTS (difficulties reported by 2-3% of individuals), and worst in those with all three ICS symptom groups (difficulties reported by 29-38% of individuals; p = 0.001). Mean HADS scores showed significantly worse (p < 0.001) levels of anxiety and depression among individuals with versus without LUTS: anxiety, 6.5 (SD, 3.7) and 4.0 (3.3); corresponding mean depression scores were 6.8 (4.3) and 4.2 (3.6). Increasing OAB severity was also associated with decreasing HRQoL physical and mental health scores.

conclusionLUTS and increasing OAB severity are both associated with impaired QoL, reduced workplace productivity, and increased tendency towards anxiety and depression. These results highlight the need to ensure that individuals with LUTS receive appropriate, effective treatment.

trial registrationClinicalTrials.gov identifier: NCT02618421 , registered 26 November 2015 (retrospectively registered).

Indexed as

Lower Urinary Tract SymptomsMental HealthQuality of LifeUrinary Bladder, OveractiveAdultAgedAnxietyChinaCross-Sectional StudiesDepressionEfficiencyFemaleHumansMaleMiddle AgedRepublic of KoreaAsiaEpidemiologyLower urinary tract symptomsMental healthPrevalenceQuality of life

Identifiers

PMID29162085
PMCPMC5698954
OpenAlexW2768283984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.