Observational studyBMC pulmonary medicine2017
Long-term prognosis of chronic cough: a prospective, observational cohort study.
Observational study in BMC pulmonary medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Pooled it
- Chronic cough: more than just a persistent cough: a systematic literature review to understand the impact of chronic cough on quality of life.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Pooled it
- Trial
- Trial
- Validation of a visual analog scale for assessing cough severity in patients with chronic cough.Therapeutic advances in respiratory diseaseTrial
- Risk of pneumonia in adults with chronic cough: a nationwide cohort study.BMJ open respiratory research · 2026Article
- When Refractory Is Not the End: Redefining Chronic Cough Through Tertiary Center Evaluation.Mayo Clinic proceedings. Innovations, quality & outcomes · 2026Article
- Association between heavy metal exposure and chronic cough: the mediating roles of inflammation.Annals of medicine · 2025Article
- Voice problems in chronic cough: prevalence and implications for health and sick leave in a Northern European population.BMC pulmonary medicine · 2025Article
- Etiologies and Treatment Outcomes of Chronic Cough Diagnosed with a Pathophysiological Diagnostic Procedure: A Single-center Retrospective Observational Cohort StudyThoracic research and practice · 2025Article
- Chronic tic cough in adults: a case report.Frontiers in medicine · 2025Article
- Chronic cough as a disease.ERJ open research · 2024Review
- Prevalence, clinical characteristics, and disease burden of chronic cough in Italy: a cross-sectional study.BMC pulmonary medicine · 2024Article
- Knowledge, attitude, and practice of healthcare providers on chronic refractory cough: A cross-sectional study.Heliyon · 2024Article
- Characteristics, demographics, and epidemiology of possible chronic cough in Sweden: A nationwide register-based cohort study.PloS one · 2024Article
- Gender Differences in Antitussive Prescriptions for Chronic Cough in Korea.Journal of clinical medicine · 2023Article
- New Insights Into Refractory Chronic Cough and Unexplained Chronic Cough: A 6-Year Ambispective Cohort Study.Allergy, asthma & immunology research · 2023Article
- Observational
- Health-Related Quality of Life and Its Determinants in Chronic Cough: The Korean Chronic Cough Registry Study.Allergy, asthma & immunology research · 2023Article
- The demographics, clinical characteristics and quality of life of patients with chronic cough from the Isala Cough Clinic in the Netherlands.ERJ open research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe long-term prognosis of chronic cough and its determinants need to be clarified.
methodsThis is a prospective, observational cohort study. Eighty-nine unselected subjects with chronic (> 8 weeks' duration) cough were carefully investigated: Clinical examination, symptom questionnaire, Leicester Cough Questionnaire (LCQ), skin prick tests, ambulatory peak expiratory flow monitoring, spirometry before and after 0.4 mgs of salbutamol, exhaled nitric oxide concentration measurement, hypertonic saline cough provocation test, and histamine bronchial provocation test. After five years, a letter was sent to the subjects containing questions about continuation of cough, smoking, indoor exposures, presence of co-morbidities, and current medication. It also contained LCQ and Cough Clinic diagnostic questionnaire. Sixty-eight subjects (76%) responded.
resultsAt five years, continuing regular cough was present in 31 (46%) of the subjects and continuing impairment in cough-related quality of life (less than 1.3 points' improvement in LCQ) in 32 (47%). Continuing regular cough was associated with presence of chronic rhinitis or esophageal reflux disease, baseline mild airway responsiveness to histamine, and baseline strong cough responsiveness to hypertonic saline. Continuing impairment in cough-related quality of life was associated with high body mass index, absence of atopy, absence of pets, and high number of background disorders (esophageal reflux disease, asthma, or chronic rhinitis).
conclusionsAlmost half of subjects with chronic cough suffered of the disorder at five years from initial assessment. Several possible determinants of poor prognosis could be identified.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.