Evidence map›Paper›PMID 29161917›Full record

ArticleIntegrative cancer therapies2018

Baker's Yeast Sensitizes Metastatic Breast Cancer Cells to Paclitaxel In Vitro.

Nariman K Badr El-Din, Ashraf Z Mahmoud, Tahia Ali Hassan, Mamdooh Ghoneum

Abstract read
In one paragraph

Article in Integrative cancer therapies, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nariman K Badr El-Din1 University of Mansoura, Mansoura, Egypt.
Ashraf Z Mahmoud1 University of Mansoura, Mansoura, Egypt.
Tahia Ali Hassan1 University of Mansoura, Mansoura, Egypt.
Mamdooh Ghoneum2 Drew University of Medicine and Science, Los Angeles, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our earlier studies have demonstrated that phagocytosis of baker's yeast ( Saccharomyces cerevisiae) induces apoptosis in different cancer cell lines in vitro and in vivo. This study aimed to examine how baker's yeast sensitizes murine and human breast cancer cells (BCC) to paclitaxel in vitro. This sensitizing effect makes lower concentrations of chemotherapy more effective at killing cancer cells, thereby enhancing the capacity of treatment. Three BCC lines were used: the metastatic murine 4T1 line, the murine Ehrlich ascites carcinoma (EAC) line, and the human breast cancer MCF-7 line. Cells were cultured with different concentrations of paclitaxel in the presence or absence of baker's yeast. Cell survival and the IC

Indexed as

ApoptosisBreast NeoplasmsCell Line, TumorCell ProliferationCell SurvivalChemotherapy, AdjuvantDNA DamageHumansMCF-7 CellsPaclitaxelSaccharomyces cerevisiaePaclitaxel4T1apoptosisbreast cancerpaclitaxelSaccharomyces cerevisiae

Identifiers

PMID29161917
PMCPMC6041900

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.