Evidence map›Paper›PMID 29161564›Full record

ArticleCurrent biology : CB2017

Cell Biology: When Your Own Chromosomes Act like Foreign DNA.

Alexander Spektor, Neil T Umbreit, David Pellman

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Current biology : CB, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Alexander SpektorHoward Hughes Medical Institute, Chevy Chase, MD, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, MA, USA.
Neil T UmbreitHoward Hughes Medical Institute, Chevy Chase, MD, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
David PellmanHoward Hughes Medical Institute, Chevy Chase, MD, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. Electronic address: David_Pellman@dfci.harvard.edu.
Howard Hughes Medical Institute · USBrigham and Women's Hospital · US

Funding

Polyploidy, Aneuploidy and Genome StabilityR01CA213404 · NCI · DANA-FARBER CANCER INST · PI PELLMAN, DAVID S · 2017 to 2024
$3.5M
The mechanism of DNA damage and chromothripsis from chromosome segregation errorsK08CA208008 · NCI · DANA-FARBER CANCER INST · PI SPEKTOR, ALEXANDER · 2016 to 2020
$886k
Medical Research Council MC_PC_15075NCI NIH HHS K08 CA208008NCI NIH HHS R01 CA213404
6 · The paper itself

Abstract

Two recent papers report the activation of a pro-inflammatory response by cytoplasmic DNA from aberrant nuclear structures called micronuclei. The findings have implications for tumor immunity, immunotherapy biomarker discovery, and possibly the many-sided effects of senescence-associated secretory phenotype.

Indexed as

ChromosomesGenomic InstabilityCellular SenescenceDNADNA DamageHumansImmunity, InnateNucleotidyltransferasesDNANucleotidyltransferases

Identifiers

PMID29161564
OpenAlexW2770386037

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.