ArticleMathematical medicine and biology : a journal of the IMA2018
Fluid dynamics in heart development: effects of hematocrit and trabeculation.
Article in Mathematical medicine and biology : a journal of the IMA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- A fluid-structure interaction model of the zebrafish aortic valve.Journal of biomechanics · 2025Article
- Hemodynamics During Development and Postnatal Life.Advances in experimental medicine and biology · 2024Review
- Recent advances in quantifying the mechanobiology of cardiac development via computational modeling.Current opinion in biomedical engineering · 2023Article
- Fluid mechanics of the zebrafish embryonic heart trabeculation.PLoS computational biology · 2022Article
- On the Lagrangian-Eulerian Coupling in the Immersed Finite Element/Difference Method.Journal of computational physics · 2022Article
- Capturing functional relations in fluid-structure interaction via machine learning.Royal Society open science · 2022Article
- A semi-automated finite difference mesh creation method for use with immersed boundary software IB2d and IBAMR.Bioinspiration & biomimetics · 2020Article
- Uncertainty quantification reveals the physical constraints on pumping by peristaltic hearts.Journal of the Royal Society, Interface · 2020Article
- An Immersed Interface Method for Discrete Surfaces.Journal of computational physics · 2020Article
- Vortex Dynamics in Trabeculated Embryonic Ventricles.Journal of cardiovascular development and disease · 2019Article
- Quantifying blood flow dynamics during cardiac development: demystifying computational methods.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Influence of blood flow on cardiac development.Progress in biophysics and molecular biology · 2018Review
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Authors and funding
4 authors.
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Abstract
Recent in vivo experiments have illustrated the importance of understanding the haemodynamics of heart morphogenesis. In particular, ventricular trabeculation is governed by a delicate interaction between haemodynamic forces, myocardial activity, and morphogen gradients, all of which are coupled to genetic regulatory networks. The underlying haemodynamics at the stage of development in which the trabeculae form is particularly complex, given the balance between inertial and viscous forces. Small perturbations in the geometry, scale, and steadiness of the flow can lead to changes in the overall flow structures and chemical morphogen gradients, including the local direction of flow, the transport of morphogens, and the formation of vortices. The immersed boundary method was used to solve the two-dimensional fluid-structure interaction problem of fluid flow moving through a two chambered heart of a zebrafish (Danio rerio), with a trabeculated ventricle, at 96 hours post fertilization (hpf). Trabeculae heights and hematocrit were varied, and simulations were conducted for two orders of magnitude of Womersley number, extending beyond the biologically relevant range (0.2-12.0). Both intracardial and intertrabecular vortices formed in the ventricle for biologically relevant parameter values. The bifurcation from smooth streaming flow to vortical flow depends upon the trabeculae geometry, hematocrit, and Womersley number, $Wo$. This work shows the importance of hematocrit and geometry in determining the bulk flow patterns in the heart at this stage of development.
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