Evidence map›Paper›PMID 29161362›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2018

The Hierarchical Organization of the Default, Dorsal Attention and Salience Networks in Adolescents and Young Adults.

Yuan Zhou, Karl J Friston, Peter Zeidman, Jie Chen, Shu Li, Adeel Razi

Abstract readTwin Study
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Rostral anterior cingulate network effective connectivity in depressed adolescents and associations with treatment response in a randomized controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
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  4. Trial
  5. Effective connectivity changes in LSD-induced altered states of consciousness in humans.Proceedings of the National Academy of Sciences of the United States of America · 2019
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  6. Review
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  18. Neurodevelopmental Pathways from Temperamental Fear to Anxiety.Current topics in behavioral neurosciences · 2025
    Review
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  20. Article

31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yuan ZhouCAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing 100101, China.
Karl J FristonThe Wellcome Trust Centre for Neuroimaging, University College London, Queen Square, London WC1N 3BG, UK.
Peter ZeidmanThe Wellcome Trust Centre for Neuroimaging, University College London, Queen Square, London WC1N 3BG, UK.
Jie ChenDepartment of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China.
Shu LiCAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing 100101, China.
Adeel RaziThe Wellcome Trust Centre for Neuroimaging, University College London, Queen Square, London WC1N 3BG, UK.

Funding

Wellcome TrustWellcome Trust 088130/Z/09/Z
6 · The paper itself

Abstract

An important characteristic of spontaneous brain activity is the anticorrelation between the core default network (cDN) and the dorsal attention network (DAN) and the salience network (SN). This anticorrelation may constitute a key aspect of functional anatomy and is implicated in several brain disorders. We used dynamic causal modeling to assess the hypothesis that a causal hierarchy underlies this anticorrelation structure, using resting-state fMRI of healthy adolescent and young adults (N = 404). Our analysis revealed an asymmetric effective connectivity, such that the regions in the SN and DAN exerted an inhibitory influence on the cDN regions; whereas the cDN exerted an excitatory influence on the SN and DAN regions. The relative strength of efferent versus afferent connections places the SN at the apex of the hierarchy, suggesting that the SN modulates anticorrelated networks with descending hierarchical connections. In short, this study of directed neuronal coupling reveals a causal hierarchical architecture that generates or orchestrates anticorrelation of brain activity. These new findings shed light on functional integration of intrinsic brain networks at rest and speak to future dynamic causal modeling studies of large-scale networks.

Indexed as

AdolescentAttentionBrainFemaleHumansMagnetic Resonance ImagingMaleNerve NetPrincipal Component AnalysisYoung Adultdefault networkdorsal attention networkdynamic causal modelingresting-state fMRIsalience network

Identifiers

PMID29161362
PMCPMC5929108

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.