ArticleBiology of reproduction2018
Distinct reorganization of collagen architecture in lipopolysaccharide-mediated premature cervical remodeling.
Article in Biology of reproduction, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prior Spontaneous or Induced Abortion Is a Risk Factor for Cervical Dysfunction in Pregnant Women: a Systematic Review and Meta-analysis.Reproductive sciences (Thousand Oaks, Calif.) · 2023Pooled it
- Spectroscopic photoacoustic imaging of cervical tissue composition in excised human samples.PloS one · 2021Trial
- Extracellular matrix reorganization during endometrial decidualization.Histochemistry and cell biology · 2025Article
- Multi-parametric quantitative evaluation of murine cervical remodeling during pregnancy and postpartum.Scientific reports · 2025Article
- Lysyl Oxidases Are Necessary for Myometrial Contractility and On-time Parturition in Mice.Journal of the Endocrine Society · 2025Article
- Collagen turnover during cervical remodeling involves both intracellular and extracellular collagen degradation pathways†.Biology of reproduction · 2025Article
- Article
- Expression of Stemness Markers in the Cervical Smear of Patients with Cervical Insufficiency.Cells · 2023Article
- Collagen and elastic fiber remodeling in the pregnant mouse myometrium†.Biology of reproduction · 2022Article
- Characterization of an Adapted Murine Model of Intrauterine Inflammation-Induced Preterm Birth.The American journal of pathology · 2020Article
- Mechanics of cervical remodelling: insights from rodent models of pregnancy.Interface focus · 2019Review
- Photoacoustic imaging of the uterine cervix to assess collagen and water content changes in murine pregnancy.Biomedical optics express · 2019Article
- Mouse models of preterm birth: suggested assessment and reporting guidelines.Biology of reproduction · 2018Review
- The mechanical response of the mouse cervix to tensile cyclic loading in term and preterm pregnancy.Acta biomaterialia · 2018Article
- Transcriptome signature identifies distinct cervical pathways induced in lipopolysaccharide-mediated preterm birth.Biology of reproduction · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Previous work has identified divergent mechanisms by which cervical remodeling is achieved in preterm birth (PTB) induced by hormone withdrawal (mifepristone) or lipopolysaccharide (LPS). Our current study aims to document how collagen architecture is modified to achieve premature cervical remodeling in mice treated with LPS as a model of infection-induced inflammation. Cervices were collected on gestation day (d) 15 from mice with premature cervical ripening induced by LPS and compared to d15 and d18 controls as well as a hormone withdrawal PTB model. Second harmonic generation (SHG) and electron microscopy were utilized for visualization of collagen morphology and ultrastructure. LPS-mediated premature cervical ripening is characterized by unique structural changes in collagen fiber morphology. LPS treatment increased the interfibrillar spacing of collagen fibrils. A preferential disruption of collagen fiber architecture in the subepithelial region compared to midstroma region was evidenced by increased pores lacking collagen signal in SHG images in the LPS-treated mice. Coinciding with this alteration, the infiltration of neutrophils was concentrated in the subepithelial stromal region as compared to midstromal region implicating the potential role of immune cells to extracellular matrix reorganization in inflammation-induced preterm cervical ripening. The current study demonstrates a preferential disorganization of collagen interfibrillar spacing and collagen fiber structure in LPS-mediated ripening.
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