ArticleCerebral cortex (New York, N.Y. : 1991)2019
Prefrontal Executive Control Rescues Risk for Anxiety Associated with High Threat and Low Reward Brain Function.
Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Great Expectations: A Critical Review of and Suggestions for the Study of Reward Processing as a Cause and Predictor of Depression.Biological psychiatry · 2021Pooled it
- tDCS reduces depression and state anxiety symptoms in older adults from the augmenting cognitive training in older adults study (ACT).Brain stimulationTrial
- Orbitofrontal and Prelimbic Cortices Serve Complementary Roles in Adapting Reward Seeking to Learned Anxiety.Biological psychiatry · 2024Article
- Neurobiology and systems biology of stress resilience.Physiological reviews · 2024Review
- Functional neuroimaging of resilience to trauma: convergent evidence and challenges for future research.Psychological medicine · 2023Review
- Similarities and differences in the induction and regulation of the negative emotions fear and disgust: A functional near infrared spectroscopy study.Scandinavian journal of psychology · 2022Article
- Transgender Youth Executive Functioning: Relationships with Anxiety Symptoms, Autism Spectrum Disorder, and Gender-Affirming Medical Treatment Status.Child psychiatry and human development · 2022Article
- Greater baseline connectivity of the salience and negative affect circuits are associated with natural improvements in anxiety over time in untreated participants.Journal of affective disorders · 2021Observational
- Neurobiological Markers of Resilience to Early-Life Adversity During Adolescence.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Review
- Analysis of Psychophysiological Stress Response in Higher Education Students Undergoing Clinical Practice Evaluation.Journal of medical systems · 2019Article
- Changes in Functional Connectivity Following Treatment With Emotion Regulation Therapy.Frontiers in behavioral neuroscience · 2019Article
- Excitability regulation in the dorsomedial prefrontal cortex during sustained instructed fear responses: a TMS-EEG study.Scientific reports · 2018Article
- A Link Between Childhood Adversity and Trait Anger Reflects Relative Activity of the Amygdala and Dorsolateral Prefrontal Cortex.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Compared with neural biomarkers of risk for mental illness, little is known about biomarkers of resilience. We explore if greater executive control-related prefrontal activity may function as a resilience biomarker by "rescuing" risk associated with higher threat-related amygdala and lower reward-related ventral striatum activity. Functional MRI was used to assay baseline threat-related amygdala, reward-related ventral striatum, and executive control-related prefrontal activity in 120 young adult volunteers. Participants provided self-reported mood and anxiety ratings at baseline and follow-up. A moderation model revealed a significant three-way interaction wherein higher amygdala and lower ventral striatum activity predicted increases in anxiety in those with average or low but not high prefrontal activity. This effect was specific to anxiety, with the neural biomarkers explaining ~10% of the variance in change over time, above and beyond baseline symptoms, sex, age, IQ, presence or absence of DMS-IV diagnosis, and both early and recent stress. Our findings are consistent with the importance of top-down executive control in adaptive regulation of negative emotions, and highlight a unique combination of neural biomarkers that may identify at-risk individuals for whom the adoption of strategies to improve executive control of negative emotions may prove particularly beneficial.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.