Evidence map›Paper›PMID 29161204›Full record

Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2018

Effect of Neoadjuvant Chemoradiotherapy on Health-Related Quality of Life in Esophageal or Junctional Cancer: Results From the Randomized CROSS Trial.

Bo Jan Noordman, Mathilde G E Verdam, Sjoerd M Lagarde, Maarten C C M Hulshof, Pieter van Hagen, Mark I van Berge Henegouwen, Bas P L Wijnhoven, Hanneke W M van Laarhoven, Grard A P Nieuwenhuijzen, Geke A P Hospers and 23 more

Registry-linked trialAbstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03381651 (Different Radiation Dose of Neoadjuvant Chemoradiation Followed by Surgery in Treating Patients with Locally Advanced, Resectable Thoracic Esophageal Cancer), which is not on this map. Cited by 58 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03381651 nacompletednot on this map

Different Radiation Dose of Neoadjuvant Chemoradiation Followed by Surgery in Treating Patients with Locally Advanced, Resectable Thoracic Esophageal Cancer

TypeinterventionalSponsorZhejiang Cancer HospitalRan2018 to 2023Enrolled147ConditionsEsophageal Carcinoma, Neoadjuvant Chemoradiotherapy, SurgeryArmsHigher dose (50.4Gy/28F) of neoadjuvant chemoradiation, Lower dose (41.4Gy/23F) of neoadjuvant chemoradiation
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Assessing the impact of neoadjuvant chemotherapy and chemoradiotherapy on quality of life during treatment in esophageal cancer: a systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
    Pooled it
  2. ISDE guidelines on the management of cT2N0 esophageal cancer.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2026
    Guideline
  3. Health-related quality of life in esophageal cancer: a state-of-the-art review of patient-reported outcomes and an evidence and gap map.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2025
    Pooled it
  4. Pooled it
  5. Patient experience and quality of life during neoadjuvant therapy for pancreatic cancer: a systematic review and study protocol.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

33 authors.

Bo Jan NoordmanBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Mathilde G E VerdamBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Sjoerd M LagardeBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Maarten C C M HulshofBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Pieter van HagenBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Mark I van Berge HenegouwenBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Bas P L WijnhovenBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Hanneke W M van LaarhovenBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Grard A P NieuwenhuijzenBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Geke A P HospersBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Johannes J BonenkampBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Miguel A CuestaBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Reinoud J B BlaisseBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Olivier R BuschBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Fiebo J W Ten KateBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Geert-Jan M CreemersBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Cornelis J A PuntBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
John Th M PlukkerBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Henk M W VerheulBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Ernst J Spillenaar BilgenBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Herman van DekkenBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Maurice J C van der SangenBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Tom RozemaBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Katharina BiermannBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Jannet C BeukemaBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Anna H M PietBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Caroline M van RijBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Janny G ReindersBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Hugo W TilanusBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Ewout W SteyerbergBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Ate van der GaastBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
Mirjam A G SprangersBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.
J Jan B van LanschotBo Jan Noordman, Sjoerd M. Lagarde, Pieter van Hagen, Bas P.L. Wijnhoven, Fiebo J.W. ten Kate, Katharina Biermann, Caroline M. van Rij, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, and J. Jan B. van Lanschot, Erasmus MC-University Medical Center Rotterdam; Mathilde G.E. Verdam, Maarten C.C.M. Hulshof, Mark I. van Berge Henegouwen, Hanneke W.M. van Laarhoven, Olivier R. Busch, Fiebo J.W. ten Kate, Cornelis J.A. Punt, and Mirjam A.G. Sprangers, Academic Medical Center; Miguel A. Cuesta, Henk M.W. Verheul, and Anna H.M. Piet, Vrije Universiteit Medical Center; Herman van Dekken, St Lucas Andreas Hospital, Amsterdam; Grard A.P. Nieuwenhuijzen, Geert-Jan M. Creemers, and Maurice J.C. van der Sangen, Catharina Hospital, Eindhoven; Geke A.P. Hospers, John Th.M. Plukker, and Jannet C. Beukema, University Medical Center Groningen, Groningen; Johannes J. Bonenkamp, Cornelis J.A. Punt, and Tom Rozema, Radboud University Nijmegen Medical Center, Nijmegen; Reinoud J.B. Blaisse and Ernst J. Spillenaar Bilgen, Rijnstate Hospital; Janny G. Reinders, Arnhem Radiotherapeutic Institute, Arnhem; and Tom Rozema, Verbeeten Institute, Tilburg, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose To compare pre-agreed health-related quality of life (HRQOL) domains in patients with esophageal or junctional cancer who received neoadjuvant chemoradiotherapy (nCRT) followed by surgery or surgery alone. Secondary aims were to examine the effect of nCRT on HRQOL before surgery and the effect of surgery on HRQOL. Patients and Methods Patients were randomly assigned to nCRT (carboplatin plus paclitaxel with concurrent 41.4-Gy radiotherapy) followed by surgery or surgery alone. HRQOL was measured using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (QLQ-C30) and -Oesophageal Cancer Module (QLQ-OES24) questionnaires pretreatment and at 3, 6, 9, and 12 months postoperatively. The nCRT group also received preoperative questionnaires. Physical functioning (PF; QLQ-C30) and eating problems (EA; QLQ-OES24) were chosen as predefined primary end points. Predefined secondary end points were global QOL (GQOL; QLQ-C30), fatigue (FA; QLQ-C30), and emotional problems (EM; QLQ-OES24). Results A total of 363 patients were analyzed. No statistically significant differences in postoperative HRQOL were found between treatment groups. In the nCRT group, PF, EA, GQOL, FA, and EM scores deteriorated 1 week after nCRT (Cohen's d: -0.93, P < .001; 0.47, P < .001; -0.84, P < .001; 1.45, P < .001; and 0.32, P = .001, respectively). In both treatment groups, all end points declined 3 months postoperatively compared with baseline (Cohen's d: -1.00, 0.33, -0.47, -0.34, and 0.33, respectively; all P < .001), followed by a continuous gradual improvement. EA, GQOL, and EM were restored to baseline levels during follow-up, whereas PF and FA remained impaired 1 year postoperatively (Cohen's d: 0.52 and -0.53, respectively; both P < .001). Conclusion Although HRQOL declined during nCRT, no effect of nCRT was apparent on postoperative HRQOL compared with surgery alone. In addition to the improvement in survival, these findings support the view that nCRT according to the Chemoradiotherapy for Esophageal Cancer Followed by Surgery Study-regimen can be regarded as a standard of care.

Indexed as

Chemoradiotherapy, AdjuvantNeoadjuvant TherapyQuality of LifeAgedAntineoplastic Combined Chemotherapy ProtocolsCarboplatinEsophageal NeoplasmsEsophagectomyEsophagogastric JunctionFemaleHealth StatusHumansMaleMiddle AgedPaclitaxelRadiotherapy DosageCarboplatinPaclitaxel

Identifiers

PMID29161204

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