Evidence map›Paper›PMID 29160912›Full record

ArticleTropical medicine & international health : TM & IH2018

Low sensitivity and frequent cross-reactions in commercially available antibody detection ELISA assays for Taenia solium cysticercosis.

Hector H Garcia, Yesenia Castillo, Isidro Gonzales, Javier A Bustos, Herbert Saavedra, Louis Jacob, Oscar H Del Brutto, Patricia P Wilkins, Armando E Gonzalez, Robert H Gilman and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Tropical medicine & international health : TM & IH, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. The Brief Case: Tastes of travel-intestinal importation.Journal of clinical microbiology · 2026
    Review
  5. Systematic Evaluation of Four Cysteine Proteases (Tropical medicine and infectious disease · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Human Neurocysticercosis: An Overview.Pathogens (Basel, Switzerland) · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

Hector H GarciaCysticercosis Unit, Department of Transmissible Diseases, Instituto Nacional de Ciencias Neurologicas, Lima, Peru.
Yesenia CastilloDepartment of Microbiology, School of Sciences, Universidad Peruana Cayetano Heredia, Lima, Perú.
Isidro GonzalesCysticercosis Unit, Department of Transmissible Diseases, Instituto Nacional de Ciencias Neurologicas, Lima, Peru.
Javier A BustosDepartment of Microbiology, School of Sciences, Universidad Peruana Cayetano Heredia, Lima, Perú.
Herbert SaavedraCysticercosis Unit, Department of Transmissible Diseases, Instituto Nacional de Ciencias Neurologicas, Lima, Peru.
Louis JacobFaculty of Medicine, University of Paris, Paris, France.
Oscar H Del BruttoSchool of Medicine, Universidad Espíritu Santo-Ecuador, Guayaquil, Ecuador.
Patricia P WilkinsParasitology Services, Marathon, FI, USA.
Armando E GonzalezSchool of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Perú.
Robert H GilmanDepartment of Microbiology, School of Sciences, Universidad Peruana Cayetano Heredia, Lima, Perú.
Cysticercosis Working Group in Peru
Instituto Nacional de Ciencias NeurológicasInstituto Nacional de Enfermedades Neoplásicas · PEJohns Hopkins University · USMarathon Oil (United States) · USUniversidad de Especialidades Espíritu Santo · ECUniversité Paris Cité · FR

Funding

Training in Parasitic Diseases and Central Nervous System Infections in Peru.D43TW001140 · FIC · UNIVERSIDAD PERUANA CAYETANO HEREDIA · PI GARCIA, HECTOR HUGO, GILMAN, ROBERT H · 1999 to 2025
$5.7M
FIC NIH HHS D43 TW001140Medical Research Council MR/K007467/1
6 · The paper itself

Abstract

objectiveTo evaluate the diagnostic performance of two commercially available ELISA kits, Novalisa

methodsArchive serum samples from patients with viable NCC (n = 45) or resolved, calcified NCC (n = 45), as well as sera from patients with other cestode parasites (hymenolepiasis, n = 45 and cystic hydatid disease, n = 45), were evaluated for cysticercosis antibody detection using two ELISA kits, Novalisa

resultsCompared to LLGP-EITB, the sensitivity of both ELISA assays to detect specific antibodies in patients with viable NCC was low (44.4% and 22.2%), and for calcified NCC, it was only 6.7% and 4.5%. Sera from patients with cystic hydatid disease were highly cross-reactive in both ELISA assays (38/45, 84.4%; and 25/45, 55.6%). Sera from patients with hymenolepiasis cross-reacted in five cases in one of the assays (11.1%) and in only one sample with the second assay (2.2%).

conclusionsThe performance of Novalisa

Indexed as

AnimalsAntigens, HelminthEnzyme-Linked Immunosorbent AssayImmunologic TestsImmunomagnetic SeparationNeurocysticercosisSensitivity and SpecificityTaenia soliumAntigens, HelminthantibodyanticorpscysticercosecysticercosisELISAneurocysticercoseneurocysticercosisPérouPeruTaenia solium

Identifiers

PMID29160912
PMCPMC5760338
OpenAlexW2768139584

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.