ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2018
Dietary Advanced Glycation End Products Have Sex- and Age-Dependent Effects on Vertebral Bone Microstructure and Mechanical Function in Mice.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 34 citations in OpenAlex.
- Association between metabolism and low back pain: a cross-sectional study.Journal of orthopaedic surgery and research · 2025Article
- Impacts of Nonenzymatic Glycation Crosslinks in Bone Matrix on the Mechanosensitivity of Osteocyte.Calcified tissue international · 2025Article
- Review
- Advanced glycation end-product accumulation differs by location and sex in aged osteoarthritic human menisci.Osteoarthritis and cartilage · 2023Article
- Accumulation of fluorescent advanced glycation end products and carboxymethyl-lysine in human cortical and trabecular bone.Bone reports · 2022Article
- Bone matrix quality in a developing high-fat diet mouse model is altered by RAGE deletion.Bone · 2022Article
- Association of skin autofluorescence with low bone density/osteoporosis and osteoporotic fractures in type 2 diabetes mellitus.Journal of diabetes · 2022Article
- High fat diet causes inferior vertebral structure and function without disc degeneration in RAGE-KO mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- The degenerative impact of hyperglycemia on the structure and mechanics of developing murine intervertebral discs.JOR spine · 2022Article
- Non-Obese MKR Mouse Model of Type 2 Diabetes Reveals Skeletal Alterations in Mineralization and Material Properties.JBMR plus · 2022Article
- Advances in research on fat infiltration and lumbar intervertebral disc degeneration.Frontiers in endocrinology · 2022Review
- Experimental Animal Studies Support the Role of Dietary Advanced Glycation End Products in Health and Disease.Nutrients · 2021Review
- Complications in the spine associated with type 2 diabetes: The role of advanced glycation end-products.Medicine in novel technology and devices · 2021Article
- Dietary AGEs as Exogenous Boosters of Inflammation.Nutrients · 2021Review
- Altered mechanical behavior of demineralized bone following therapeutic radiation.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Article
- Skin Autofluorescence, a Noninvasive Biomarker for Advanced Glycation End-Products, Is Associated With Prevalent Vertebral and Major Osteoporotic Fractures: The Rotterdam Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020Article
- Dietary Advanced Glycation End-Products (dAGEs) Intake and Bone Health: A Cross-Sectional Analysis in the Rotterdam Study.Nutrients · 2020Article
- The BALB/c mouse as a preclinical model of the age-related deterioration in the lumbar vertebra.Bone · 2020Article
- Kinematic Changes in a Mouse Model of Penetrating Hippocampal Injury and Their Recovery After Intranasal Administration of Endometrial Mesenchymal Stem Cell-Derived Extracellular Vesicles.Frontiers in cellular neuroscience · 2020Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Back pain is a leading cause of global disability that can arise from vertebral fracture and osteoporosis. Although poor general health and obesity are among the strongest risk factors for back pain, there is remarkably little known about how diet influences spinal diseases. Advanced glycation end-products (AGEs) are implicated in increased fracture risk, yet no studies investigated how dietary AGEs affect spinal health. We tested the hypothesis that high dietary AGE ingestion will diminish vertebral structure and function in a sex- and age-dependent manner. Female and male mice were fed low-AGE (L-AGE) or high-AGE (H-AGE) isocaloric diets for 6 and 18 months and multiple measurements of bone structure and function were taken. AGE levels in serum and cortical vertebrae were increased only for 6-month-old H-AGE female mice while blood glucose and body weight remained normal for all animals. When fed an H-AGE diet, 6-month-old female mice had inferior vertebral trabecular structure with decreased bone mineral density (BMD) and bone volume fraction. Biomechanical testing and analytical modeling further showed functional deterioration in 6-month-old H-AGE females with reduced shear and compression moduli, and maximum load to failure. At 18 months, H-AGE mice of both sexes had significant but small decreases in cortical BMD and thickness, yet functional biomechanical behaviors were not distinguishable from other aging changes. We conclude that an H-AGE diet, without diabetic or overweight conditions, diminished vertebral microstructure, mechanical behaviors, and fracture resistance in young female mice in a manner suggesting accelerated bone aging. © 2017 American Society for Bone and Mineral Research.
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