Evidence map›Paper›PMID 29160839›Full record

ArticleMolecules (Basel, Switzerland)2017

Inkjet Printing of Drug-Loaded Mesoporous Silica Nanoparticles-A Platform for Drug Development.

Henrika Wickström, Ellen Hilgert, Johan O Nyman, Diti Desai, Didem Şen Karaman, Thomas de Beer, Niklas Sandler, Jessica M Rosenholm

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
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  16. Article
  17. Article
  18. Novel Biomaterials Used in Medical 3D Printing Techniques.Journal of functional biomaterials · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Henrika WickströmPharmaceutical Sciences Laboratory, Åbo Akademi University, FI-20520 Turku, Finland. henrika.wickstrom@abo.fi.
Ellen HilgertPharmaceutical Sciences Laboratory, Åbo Akademi University, FI-20520 Turku, Finland. ellen@hilgert.be.
Johan O NymanPharmaceutical Sciences Laboratory, Åbo Akademi University, FI-20520 Turku, Finland. johan.o.nyman@abo.fi.
Diti DesaiPharmaceutical Sciences Laboratory, Åbo Akademi University, FI-20520 Turku, Finland. diti.desai@gmail.com.
Didem Şen KaramanPharmaceutical Sciences Laboratory, Åbo Akademi University, FI-20520 Turku, Finland. didem.sen@abo.fi.
Thomas de BeerLaboratory of Pharmaceutical Process Analytical Technology, Ghent University, B-9000 Ghent, Belgium. Thomas.DeBeer@ugent.be.
Niklas SandlerPharmaceutical Sciences Laboratory, Åbo Akademi University, FI-20520 Turku, Finland. niklas.sandler@abo.fi.
Jessica M RosenholmPharmaceutical Sciences Laboratory, Åbo Akademi University, FI-20520 Turku, Finland. jessica.rosenholm@abo.fi.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesoporous silica nanoparticles (MSNs) have shown great potential in improving drug delivery of poorly water soluble (BCS class II, IV) and poorly permeable (BCS class III, IV) drugs, as well as facilitating successful delivery of unstable compounds. The nanoparticle technology would allow improved treatment by reducing adverse reactions of currently approved drugs and possibly reintroducing previously discarded compounds from the drug development pipeline. This study aims to highlight important aspects in mesoporous silica nanoparticle (MSN) ink formulation development for digital inkjet printing technology and to advice on choosing a method (2D/3D) for nanoparticle print deposit characterization. The results show that both unfunctionalized and polyethyeleneimine (PEI) surface functionalized MSNs, as well as drug-free and drug-loaded MSN-PEI suspensions, can be successfully inkjet-printed. Furthermore, the model BCS class IV drug remained incorporated in the MSNs and the suspension remained physically stable during the processing time and steps. This proof-of-concept study suggests that inkjet printing technology would be a flexible deposition method of pharmaceutical MSN suspensions to generate patterns according to predefined designs. The concept could be utilized as a versatile drug screening platform in the future due to the possibility of accurately depositing controlled volumes of MSN suspensions on various materials.

Indexed as

Drug Delivery SystemsNanoparticlesPrintingSilicon DioxideDrug CarriersDrug StabilityParticle SizePharmaceutical PreparationsPorosityDrug CarriersPharmaceutical PreparationsSilicon Dioxidedigital printingdrug deliveryinkjet printing technologymesoporous silica nanoparticlespharmaceutical nanosuspensionprint morphologyscreening platform

Identifiers

PMID29160839
PMCPMC6150386

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.