Evidence map›Paper›PMID 29160835›Full record

ReviewInternational journal of molecular sciences2017

Vitamin D and Neurological Diseases: An Endocrine View.

Carolina Di Somma, Elisabetta Scarano, Luigi Barrea, Volha V Zhukouskaya, Silvia Savastano, Chiara Mele, Massimo Scacchi, Gianluca Aimaretti, Annamaria Colao, Paolo Marzullo

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06791044 (25), which is not on this map. Cited by 77 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 1 pooled it
19.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06791044 narecruitingnot on this mapstarted 2025, after this paper: background citation

25(OH)-Vitamin D and Its Association With Bone Density, Body Composition, Strength, Walking Speed, Physical Performance and Pain in Hospitalized Individuals With Neurological Disorders

TypeinterventionalSponsorDionyssiotis, Yannis, M.D.Ran2025 to 2027Enrolled120ConditionsVitamin D InsufficiencyArmsDELTIUS
3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 1 synthesis or guideline pooled it, 230 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  4. Article
  5. Maternal Mushroom Consumption During Pregnancy Is Associated With Decreased Risk of Peer Problems and Decreased Risk of Low Prosocial Behavior in 5-Year-Olds.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
    Article
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  15. Article
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  18. Crosstalk between bone and brain in Alzheimer's disease: Mechanisms, applications, and perspectives.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Review
  19. Role of Calcitriol and Vitamin D Receptor (International journal of molecular sciences · 2024
    Review
  20. Review

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Carolina Di SommaIRCCS SDN, Napoli Via Gianturco 113, 80143 Naples, Italy. cdisomma@unina.it.
Elisabetta ScaranoDipartimento di Medicina Clinica e Chirurgia, Divisione di Endocrinologia Università "Federico II" Napoli, 80138 Napoli, Italy. el.scarano@gmail.com.
Luigi BarreaI.O.S. & COLEMAN Srl, 80011 Napoli, Italy. luigi.barrea@unina.it.ORCID 0000-0001-9054-456X
Volha V ZhukouskayaDipartimento di Medicina Clinica e Chirurgia, Divisione di Endocrinologia Università "Federico II" Napoli, 80138 Napoli, Italy. volha.zhukouskaya@gmail.com.
Silvia SavastanoDipartimento di Medicina Clinica e Chirurgia, Divisione di Endocrinologia Università "Federico II" Napoli, 80138 Napoli, Italy. sisavast@unina.it.
Chiara MeleDivision of General Medicine, IRCCS Istituto Auxologico Italiano, Ospedale S. Giuseppe, Via Cadorna 90, 28824 Piancavallo VB, Italy. chiara.mele1989@gmail.com.
Massimo ScacchiDivision of General Medicine, IRCCS Istituto Auxologico Italiano, Ospedale S. Giuseppe, Via Cadorna 90, 28824 Piancavallo VB, Italy. massimo.scacchi@unimi.it.ORCID 0000-0002-4624-9114
Gianluca AimarettiDepartment of Translational Medicine, University of Piemonte Orientale, Via Solaroli 17, 28100 Novara, Italy. gianluca.aimaretti@med.uniupo.it.
Annamaria ColaoDipartimento di Medicina Clinica e Chirurgia, Divisione di Endocrinologia Università "Federico II" Napoli, 80138 Napoli, Italy. colao@unina.it.
Paolo MarzulloDivision of General Medicine, IRCCS Istituto Auxologico Italiano, Ospedale S. Giuseppe, Via Cadorna 90, 28824 Piancavallo VB, Italy. paolo.marzullo@med.uniupo.it.ORCID 0000-0003-3215-5747
University of Naples Federico II · ITUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITSDN Istituto di Ricerca Diagnostica e Nucleare · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin D system comprises hormone precursors, active metabolites, carriers, enzymes, and receptors involved in genomic and non-genomic effects. In addition to classical bone-related effects, this system has also been shown to activate multiple molecular mediators and elicit many physiological functions. In vitro and in vivo studies have, in fact, increasingly focused on the "non-calcemic" actions of vitamin D, which are associated with the maintenance of glucose homeostasis, cardiovascular morbidity, autoimmunity, inflammation, and cancer. In parallel, growing evidence has recognized that a multimodal association links vitamin D system to brain development, functions and diseases. With vitamin D deficiency reaching epidemic proportions worldwide, there is now concern that optimal levels of vitamin D in the bloodstream are also necessary to preserve the neurological development and protect the adult brain. The aim of this review is to highlight the relationship between vitamin D and neurological diseases.

Indexed as

AnimalsBiomarkersDisease SusceptibilityHomeostasisHormonesHumansNervous System DiseasesVitamin DBiomarkersHormonesVitamin Dbiomarkerhormonesneurological diseasevitamin D

Identifiers

PMID29160835
PMCPMC5713448
OpenAlexW2770085448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.