Evidence map›Paper›PMID 29160205›Full record

ArticleeLife2017

Clarinet (CLA-1), a novel active zone protein required for synaptic vesicle clustering and release.

Zhao Xuan, Laura Manning, Jessica Nelson, Janet E Richmond, Daniel A Colón-Ramos, Kang Shen, Peri T Kurshan

Abstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed.

  1. Article
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  16. Conserved autism-associated genes tune social feeding behavior inbioRxiv : the preprint server for biology · 2023
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  17. The epithelial NaCell reports · 2023
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  18. The role of specific isoforms of CaScientific reports · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhao Xuan *Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, United States.ORCID http://orcid.org/0000-0002-8254-2887
Laura Manning *Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois.ORCID http://orcid.org/0000-0003-1597-0600
Jessica NelsonProgram in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, United States.
Janet E RichmondDepartment of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois.
Daniel A Colón-RamosProgram in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, United States.
Kang ShenDepartment of Biology, Stanford University, Stanford, United States.ORCID http://orcid.org/0000-0003-4059-8249
Peri T KurshanDepartment of Biology, Stanford University, Stanford, United States.ORCID http://orcid.org/0000-0001-6267-7103

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Cellular and molecular mechanisms that temporally and spatially restrict synapticR01NS076558 · NINDS · YALE UNIVERSITY · PI COLON-RAMOS, DANIEL A · 2012 to 2022
$4.1M
Mechanisms of Synaptic Specificity in C. elegansR01NS048392 · NINDS · STANFORD UNIVERSITY · PI SHEN, KANG · 2005 to 2014
$3.1M
Howard Hughes Medical InstituteNIH HHS P40 OD010440NINDS NIH HHS R01 NS048392NINDS NIH HHS R01 NS076558
6 · The paper itself

Abstract

Active zone proteins cluster synaptic vesicles at presynaptic terminals and coordinate their release. In forward genetic screens, we isolated a novel

Indexed as

AnimalsBiological TransportCaenorhabditis elegansCaenorhabditis elegans ProteinsNerve Tissue ProteinsPresynaptic TerminalsSynaptic VesiclesVesicular Transport ProteinsCaenorhabditis elegans ProteinsCLA-1 protein, C elegansNerve Tissue ProteinsVesicular Transport Proteinsactive zoneC. eleganscell biologyneurosciencepresynaptic plasticitysynapsesynaptic vesiclesynaptogenesis

Identifiers

PMID29160205
PMCPMC5728718

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.