Evidence map›Paper›PMID 29160204›Full record

ArticleeLife2017

Proteins acting out of (dis)order.

David Eliezer

Abstract readComment
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

David EliezerDepartment of Biochemistry, Weill Cornell Medical College, New York, United States.ORCID 0000-0002-1311-7537

Funding

Structure and Function of Alpha-SynucleinR37AG019391 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI ELIEZER, DAVID · 2010 to 2019
$3.4M
Structure and Function of Alpha-SynucleinR01AG019391 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI ELIEZER, DAVID · 2001 to 2009
$2.6M
Structure and Function of ComplexinR01GM117518 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI ELIEZER, DAVID · 2016 to 2019
$1.3M
Structure and Function of TauR01AG025440 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI ELIEZER, DAVID · 2005 to 2008
$1.2M
NIA NIH HHS R01 AG019391NIA NIH HHS R01 AG025440NIA NIH HHS R37 AG019391NIGMS NIH HHS R01 GM117518
6 · The paper itself

Abstract

A disordered region at the N-terminus of the glucocorticoid receptor can fine tune how cells respond to a hormone via an allosteric mechanism.

Indexed as

Acting OutFrustrationAllosteric RegulationModels, MolecularTranscription FactorsTranscription Factorsallosterybiophysicsdisorderfrustrationnonestructural biology

Identifiers

PMID29160204
PMCPMC5697927

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.