Evidence map›Paper›PMID 29160029›Full record

ArticleAngewandte Chemie (International ed. in English)2018

Dose Dependencies and Biocompatibility of Renal Clearable Gold Nanoparticles: From Mice to Non-human Primates.

Jing Xu, Mengxiao Yu, Chuanqi Peng, Phoebe Carter, Jia Tian, Xuhui Ning, Qinhan Zhou, Qiu Tu, Greg Zhang, Anthony Dao and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  7. Article
  8. Charge barriers in the kidney elimination of engineered nanoparticles.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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  11. Review
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  18. Review
  19. Article
  20. Renal clearable nanocarriers: Overcoming the physiological barriers for precise drug delivery and clearance.Journal of controlled release : official journal of the Controlled Release Society · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jing XuDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080, USA.
Mengxiao YuDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080, USA.
Chuanqi PengDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080, USA.
Phoebe CarterDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080, USA.
Jia TianGeneral Research Institute for Nonferrous Metals, 2 Xinjiekou Outer St., Beijing, 100088, China.
Xuhui NingDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080, USA.
Qinhan ZhouDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080, USA.
Qiu TuKunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Donglu, Kunming, 650223, China.
Greg ZhangDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080, USA.
Anthony DaoDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080, USA.
Xingya JiangDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080, USA.
Payal KapurDepartment of Pathology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA.
Jer-Tsong HsiehDepartment of Urology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA.
Xudong ZhaoKunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Donglu, Kunming, 650223, China.
Pengyu LiuGeneral Research Institute for Nonferrous Metals, 2 Xinjiekou Outer St., Beijing, 100088, China.
Jie ZhengDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080, USA.

Funding

Surface chemistry for high-contrast fluorescence kidney imagingR01DK103363 · NIDDK · UNIVERSITY OF TEXAS DALLAS · PI ZHENG, JIE · 2014 to 2018
$1.3M
NIDDK NIH HHS R01 DK103363
6 · The paper itself

Abstract

While dose dependencies in pharmacokinetics and clearance are often observed in clinically used small molecules, very few studies have been dedicated to the understandings of potential dose-dependent in vivo transport of nanomedicines. Here we report that the pharmacokinetics and clearance of renal clearable gold nanoparticles (GS-AuNPs) are strongly dose-dependent once injection doses are above 15 mg kg

Indexed as

Biocompatible MaterialsMetal NanoparticlesAnimalsArea Under CurveDose-Response Relationship, DrugGlomerular Filtration RateGoldKidneyMacaca fascicularisMiceNo-Observed-Adverse-Effect LevelPharmacokineticsSpecies SpecificityTissue DistributionBiocompatible MaterialsGoldbiocompatibilitydose dependenciesnanoparticlesnon-human primatesrenal clearance

Identifiers

PMID29160029
PMCPMC5909189

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.