Evidence map›Paper›PMID 29159998›Full record

ArticleAmerican journal of medical genetics. Part A2018

Summary of the first inaugural joint meeting of the International Consortium for scoliosis genetics and the International Consortium for vertebral anomalies and scoliosis, March 16-18, 2017, Dallas, Texas.

Philip F Giampietro, Olivier Pourquie, Cathy Raggio, Shiro Ikegawa, Peter D Turnpenny, Ryan Gray, Sally L Dunwoodie, Christina A Gurnett, Benjamin Alman, Kenneth Cheung and 3 more

Open access · greenAbstract readConference Proceedings
In one paragraph

Article in American journal of medical genetics. Part A, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 13 institutions in 5 countries.

Philip F GiampietroDrexel University College of Medicine, Philadelphia, Pennsylvania.ORCID 0000-0003-2874-8064
Olivier PourquieHarvard Medical School, Boston, Massachusetts.
Cathy RaggioHospital for Special Surgery, New York, New York.
Shiro IkegawaRIKEN Center for Integrative Medical Sciences, Tokyo, Japan.
Peter D TurnpennyRoyal Devon and Exeter Hospital, Exeter, United Kingdom.
Ryan GrayUniversity of Texas, Austin, Texas.
Sally L DunwoodieVictor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.
Christina A GurnettWashington University in St Louis, St. Louis, Missouri.
Benjamin AlmanDuke University, Durham, North Carolina.
Kenneth CheungThe University of Hong Kong, Hong Kong, China.
Kenro KusumiArizona State University, Tempe, Arizona.
Nancy Hadley-MillerUniversity of Colorado, Anschutz Medical Campus, Aurora, Colorado.
Carol A WiseTexas Scottish Rite Hospital for Children, Dallas, Texas.
Arizona State University · USDrexel University · USDuke University · USHarvard University · USHospital for Special Surgery · USRIKEN Center for Integrative Medical Sciences · JPRoyal Devon and Exeter Hospital · GBTexas Scottish Rite Hospital for Children · USThe University of Texas at Austin · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Hong Kong · HKVictor Chang Cardiac Research Institute · AUWashington University in St. Louis · US

Funding

Non-coding/epigenetic regulationP01HD084387 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI LILIANNA SOLNICAKREZEL · 2016 to 2026
$14.2M
Genetic Risk Factors for Severe ScoliosisR01AR067715 · NIAMS · WASHINGTON UNIVERSITY · PI DOBBS, MATTHEW BARRETT, GURNETT, CHRISTINA · 2015 to 2024
$6.0M
Towards a Mechanistic Undestanding of Adolscent Idiopathic ScoliosisR01AR072009 · NIAMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Ryan Scott Gray · 2017 to 2026
$3.9M
Elucidating the Cellular and Molecular Mechanisms of Late-Onset ScoliosisF32AR063001 · NIAMS · WASHINGTON UNIVERSITY · PI GRAY, RYAN SCOTT · 2012 to 2014
$163k
Genomic Approaches to Understanding and Treating ScoliosisR13HD089664 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI WISE, CAROL A · 2016 to 2016
$6k
NIAMS NIH HHS F32 AR063001NIAMS NIH HHS R01 AR067715NIAMS NIH HHS R01 AR072009NICHD NIH HHS P01 HD084387NICHD NIH HHS R13 HD089664
6 · The paper itself

Abstract

Scoliosis represents the most common musculoskeletal disorder in children and affects approximately 3% of the world population. Scoliosis is separated into two major phenotypic classifications: congenital and idiopathic. Idiopathic scoliosis is defined as a curvature of the spine of 10° or greater visualized on plane radiograph and does not have associated vertebral malformations (VM). "Congenital" scoliosis (CS) due to malformations in vertebrae is frequently associated with other birth defects. Recently, significant advances have been made in understanding the genetic basis of both conditions. There is evidence that both conditions are etiologically related. A 2-day conference entitled "Genomic Approaches to Understanding and Treating Scoliosis" was held at Scottish Rite Hospital for Children in Dallas, Texas, to synergize research in this field. This first combined, multidisciplinary conference featured international scoliosis researchers in basic and clinical sciences. A major outcome of the conference advancing scoliosis research was the proposal and subsequent vote in favor of merging the International Consortium for Vertebral Anomalies and Scoliosis (ICVAS) and International Consortium for Scoliosis Genetics (ICSG) into a single entity called International Consortium for Spinal Genetics, Development, and Disease (ICSGDD). The ICSGDD is proposed to meet annually as a forum to synergize multidisciplinary spine deformity research.

Indexed as

HumansScoliosiscongenital scoliosisGWASidiopathic scoliosisnatural historyphenotypic classificationspine deformity

Identifiers

PMID29159998
PMCPMC6525596
OpenAlexW2769489960

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.