ArticleEnvironmental microbiology2018
Sporulation capability and amylosome conservation among diverse human colonic and rumen isolates of the keystone starch-degrader Ruminococcus bromii.
Article in Environmental microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06292949 (Effect of Resistant Starch on Symptom Improvement and Intestinal Microbiome in Patients With Functional Constipation), which is not on this map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Resistant Starch on Symptom Improvement and Intestinal Microbiome in Patients With Functional Constipation
Who cites it
52 citing papers in PubMed, 98 citations in OpenAlex.
- Additional Resistant Starch from One Potato Side Dish per Day Alters the Gut Microbiota but Not Fecal Short-Chain Fatty Acid Concentrations.Nutrients · 2022Trial
- Next-generation probiotics: an outlook into current applications and future developments.Nature reviews. Microbiology · 2026Review
- Gatekeeping Dietary Fiber: The Role of Carbohydrate-Binding Modules in the Human Gut.Journal of microbiology and biotechnology · 2026Review
- Effect of resistant starch type 5 on gut health through modulating gut microbiota.Engineering microbiology · 2026Review
- Dietary β-hydroxy-β-methyl butyrate supplementation improves intestinal health and growth performance in Tibetan sheep lambs via modulating small intestinal microbiota.Journal of animal science and biotechnology · 2026Article
- Harnessing the microbiome: unveiling the influence of the gut microbiota on hepatobiliary cancer therapeutic strategies.Clinical and molecular hepatology · 2026Review
- Novel insights into carbohydrate utilisation, antimicrobial resistance, and sporulation potential inGut microbes · 2025Article
- Spatial constraints drive amylosome-mediated resistant starch degradation by Ruminococcus bromii in the human colon.Nature communications · 2025Article
- Metabolic pathways associated with Firmicutes prevalence in the gut of multiple livestock animals and humans.Animal microbiome · 2025Article
- Important roles ofFood science and biotechnology · 2024Review
- Understanding the gut microbiota by considering human evolution: a story of fire, cereals, cooking, molecular ingenuity, and functional cooperation.Microbiology and molecular biology reviews : MMBR · 2024Review
- The Ruminococcus bromii amylosome protein Sas6 binds single and double helical α-glucan structures in starch.Nature structural & molecular biology · 2024Article
- Nutrition at the Intersection between Gut Microbiota Eubiosis and Effective Management of Type 2 Diabetes.Nutrients · 2024Review
- Identification of inulin-responsive bacteria in the gut microbiota via multi-modal activity-based sorting.Nature communications · 2023Article
- Interfacial Catalysis during Amylolytic Degradation of Starch Granules: Current Understanding and Kinetic Approaches.Molecules (Basel, Switzerland) · 2023Review
- Resistant starch utilization byFood science and biotechnology · 2023Review
- Glycan-related genes in human gut microbiota exhibit differential distribution and diversity in carbohydrate degradation and glycan synthesis.Frontiers in molecular biosciences · 2023Article
- Article
- Tutorial: Microbiome studies in drug metabolism.Clinical and translational science · 2022Article
- Cryptosporulation in Kurthia spp. forces a rethinking of asporogenesis in Firmicutes.Environmental microbiology · 2022Article
Corrections and comments
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Authors and funding
19 authors at 6 institutions in 5 countries.
Funding
Abstract
Ruminococcus bromii is a dominant member of the human colonic microbiota that plays a 'keystone' role in degrading dietary resistant starch. Recent evidence from one strain has uncovered a unique cell surface 'amylosome' complex that organizes starch-degrading enzymes. New genome analysis presented here reveals further features of this complex and shows remarkable conservation of amylosome components between human colonic strains from three different continents and a R. bromii strain from the rumen of Australian cattle. These R. bromii strains encode a narrow spectrum of carbohydrate active enzymes (CAZymes) that reflect extreme specialization in starch utilization. Starch hydrolysis products are taken up mainly as oligosaccharides, with only one strain able to grow on glucose. The human strains, but not the rumen strain, also possess transporters that allow growth on galactose and fructose. R. bromii strains possess a full complement of sporulation and spore germination genes and we demonstrate the ability to form spores that survive exposure to air. Spore formation is likely to be a critical factor in the ecology of this nutritionally highly specialized bacterium, which was previously regarded as 'non-sporing', helping to explain its widespread occurrence in the gut microbiota through the ability to transmit between hosts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.