ArticleHuman brain mapping2018
Mapping the structural and functional network architecture of the medial temporal lobe using 7T MRI.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A bibliometric analysis of synaptic plasticity and epilepsy from 2003 to 2023.Frontiers in neurology · 2025Pooled it
- A multimodal epilepsy dataset of paired 3-Tesla and 7-Tesla MRI and intracranial EEG.Scientific data · 2026Article
- Bilateral cornu ammonis 3-dominant mechanism of visual working memory impairment in right temporal lobe epilepsy and hippocampal sclerosis.Brain communications · 2026Article
- Developing an Anatomically Valid Segmentation Protocol for Anterior Regions of the Medial Temporal Lobe for Neurodegenerative Diseases.Hippocampus · 2025Article
- Object fine-grained discrimination as a sensitive cognitive marker of transentorhinal integrity.Communications biology · 2025Article
- Hippocampal subfields and their neocortical interactions during autobiographical memory.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Altered structural hippocampal intra-networks in a general elderly Japanese population with mild cognitive impairment.Scientific reports · 2023Article
- Amortization Transformer for Brain Effective Connectivity Estimation from fMRI Data.Brain sciences · 2023Article
- Hippocampal anterior- posterior shift in childhood and adolescence.Progress in neurobiology · 2023Article
- Mapping hippocampal glutamate in mesial temporal lobe epilepsy with glutamate weighted CEST (GluCEST) imaging.Human brain mapping · 2023Article
- Robust dynamic brain coactivation states estimated in individuals.Science advances · 2023Article
- Brain structure-function coupling associated with cognitive impairment in cerebral small vessel disease.Frontiers in neuroscience · 2023Review
- Morphometric and microstructural characteristics of hippocampal subfields in mesial temporal lobe epilepsy and their correlates with mnemonic discrimination.Frontiers in neurology · 2023Article
- Disturbed hippocampal intra-network in first-episode of drug-naïve major depressive disorder.Brain communications · 2023Article
- Impairments of Long-Term Synaptic Plasticity in the Hippocampus of Young Rats during the Latent Phase of the Lithium-Pilocarpine Model of Temporal Lobe Epilepsy.International journal of molecular sciences · 2021Article
- Imaging human engrams using 7 Tesla magnetic resonance imaging.Hippocampus · 2021Review
- Volumetric glutamate imaging (GluCEST) using 7T MRI can lateralize nonlesional temporal lobe epilepsy: A preliminary study.Brain and behavior · 2021Article
- Brainwide functional networks associated with anatomically- and functionally-defined hippocampal subfields using ultrahigh-resolution fMRI.Scientific reports · 2021Article
- Wheels Within Wheels: Theory and Practice of Epileptic Networks.Epilepsy currents · 2021Article
- Functional connectivity of the hippocampus and its subfields in resting-state networks.The European journal of neuroscience · 2021Article
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Authors and funding
15 authors.
Funding
Abstract
Medial temporal lobe (MTL) subregions play integral roles in memory function and are differentially affected in various neurological and psychiatric disorders. The ability to structurally and functionally characterize these subregions may be important to understanding MTL physiology and diagnosing diseases involving the MTL. In this study, we characterized network architecture of the MTL in healthy subjects (n = 31) using both resting state functional MRI and MTL-focused T2-weighted structural MRI at 7 tesla. Ten MTL subregions per hemisphere, including hippocampal subfields and cortical regions of the parahippocampal gyrus, were segmented for each subject using a multi-atlas algorithm. Both structural covariance matrices from correlations of subregion volumes across subjects, and functional connectivity matrices from correlations between subregion BOLD time series were generated. We found a moderate structural and strong functional inter-hemispheric symmetry. Several bilateral hippocampal subregions (CA1, dentate gyrus, and subiculum) emerged as functional network hubs. We also observed that the structural and functional networks naturally separated into two modules closely corresponding to (a) bilateral hippocampal formations, and (b) bilateral extra-hippocampal structures. Finally, we found a significant correlation in structural and functional connectivity (r = 0.25). Our findings represent a comprehensive analysis of network topology of the MTL at the subregion level. We share our data, methods, and findings as a reference for imaging methods and disease-based research.
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