Evidence map›Paper›PMID 29159929›Full record

Observational studyActa anaesthesiologica Scandinavica2018

S100β in newborns after C-section with general vs. epidural anesthesia: a prospective observational study.

Z Xu, Z Liu, Y Zhang, C Jin, F Shen, Y Yu, T Cheek, O Onuoha, G Liang, R Month and 3 more

Abstract readComparative StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Acta anaesthesiologica Scandinavica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Z XuDepartment of Anesthesiology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0002-2696-3492
Z LiuDepartment of Anesthesiology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.
Y ZhangDepartment of Anesthesiology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.
C JinDepartment of Anesthesiology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.
F ShenDepartment of Anesthesiology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.
Y YuDepartment of Anesthesiology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.
T CheekDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
O OnuohaDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
G LiangDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
R MonthDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
J AtkinsDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
K M TranDepartment of Anesthesiology and Critical Care, Children Hospital of Philadelphia, Philadelphia, PA, USA.
H WeiDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Shanghai First Maternity and Infant Hospital · CNUniversity of Pennsylvania · USChildren's Hospital of Philadelphia · US

Funding

Mechanisms of Anesthesia Mediated NeurotoxicityR01GM084979 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI WEI, HUAFENG · 2008 to 2018
$2.8M
Mechanisms of Dantrolene Neuroprotection in Alzheimer's DiseaseR01AG061447 · NIA · UNIVERSITY OF PENNSYLVANIA · PI WEI, HUAFENG · 2019 to 2023
$2.3M
Volatile anesthetics, calcium homeostasis and apoptosisK08GM073224 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI WEI, HUAFENG · 2005 to 2009
$639k
NIA NIH HHS R01 AG061447NIGMS NIH HHS K08 GM073224NIGMS NIH HHS R01 GM084979
6 · The paper itself

Abstract

backgroundPreclinical evidence suggests that general anesthetics can dose dependently induce neurodegeneration in the developing brains of animals which can be reliably determined by measurement of blood S100β, but this correlation remains unclear in humans. We hypothesized that S100β would not be increased in cord arterial blood of fetuses exposed briefly to general anesthetics during a C-section, compared with epidural anesthesia.

methodsA prospective observational clinical study comparatively measured changes of brain damage biomarker S100β ratio of umbilical artery over vein (changes after fetus circulation) immediately after delivery under C-section with either epidural or general anesthesia. Newborn blood gas measurements, APGAR scores, and maternal well-being were also compared.

resultsCompared with epidural anesthesia, general anesthesia resulted in the lower S100β ratio of umbilical artery over the vein (medium 2.64 [quartiles 1.39, 3.45] vs. medium 1.59 [quartiles 0.88, 2.01], P = 0.031), without changing the S100β level in the vein of the mother. There was no significant difference between general and epidural anesthesia when comparing other maternal and newborn parameters.

conclusionS100β levels in newborn after C-section is lower with general anesthesia than epidural anesthesia, with unclear mechanisms.

Indexed as

Anesthesia, EpiduralAnesthesia, GeneralAnesthesia, ObstetricalCesarean SectionAdultApgar ScoreFemaleHumansInfant, NewbornMalePregnancyProspective StudiesS100 Calcium Binding Protein beta SubunitS100 Calcium Binding Protein beta Subunit

Identifiers

PMID29159929
PMCPMC5799015
OpenAlexW2771003035

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.