Evidence map›Paper›PMID 29159775›Full record

ArticleJournal of neuro-oncology2018

Toxic effects of phytol and retinol on human glioblastoma cells are associated with modulation of cholesterol and fatty acid biosynthetic pathways.

Gustavo Facchini, Raffaela Silvestre Ignarro, Erika Rodrigues-Silva, André Schwambach Vieira, Iscia Lopes-Cendes, Roger Frigério Castilho, Fabio Rogerio

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neuro-oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Targeting Oncogenic Rewiring of Lipid Metabolism for Glioblastoma Treatment.International journal of molecular sciences · 2022
    Review
  8. Metabolic Rewiring in Glioblastoma Cancer:Frontiers in oncology · 2022
    Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Gustavo FacchiniDepartment of Anatomical Pathology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Av. Tessália Vieira de Camargo, 126, Campinas, SP, Zip Code: 13083-887, Brazil.
Raffaela Silvestre IgnarroDepartment of Anatomical Pathology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Av. Tessália Vieira de Camargo, 126, Campinas, SP, Zip Code: 13083-887, Brazil.
Erika Rodrigues-SilvaDepartment of Clinical Pathology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Av. Tessália Vieira de Camargo, 126, Campinas, SP, Zip Code: 13083-887, Brazil.
André Schwambach VieiraDepartment of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), R. Monteiro Lobato, 255, Campinas, SP, Zip Code: 13083-862, Brazil.
Iscia Lopes-CendesDepartment of Medical Genetics, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Av. Tessália Vieira de Camargo, 126, Campinas, SP, Zip Code: 13083-887, Brazil.
Roger Frigério CastilhoDepartment of Clinical Pathology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Av. Tessália Vieira de Camargo, 126, Campinas, SP, Zip Code: 13083-887, Brazil.
Fabio RogerioDepartment of Anatomical Pathology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Av. Tessália Vieira de Camargo, 126, Campinas, SP, Zip Code: 13083-887, Brazil. fabio@fcm.unicamp.br.ORCID http://orcid.org/0000-0001-5712-7617
Universidade Estadual de Campinas (UNICAMP) · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2011/50400-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2013/02618-1Fundação de Amparo à Pesquisa do Estado de São Paulo 2013/07559-3Fundo de Apoio ao Ensino, à Pesquisa e Extensão, Universidade Estadual de Campinas 379/13Fundo de Apoio ao Ensino, à Pesquisa e Extensão, Universidade Estadual de Campinas 554/14Fundo de Apoio ao Ensino, à Pesquisa e Extensão, Universidade Estadual de Campinas 621/14
6 · The paper itself

Abstract

Glioblastoma (GBM) is the most common primary brain tumor. Genetic mutations may reprogram the metabolism of neoplastic cells. Particularly, alterations in cholesterol and fatty acid biosynthetic pathways may favor biomass synthesis and resistance to therapy. Therefore, compounds that interfere with those pathways, such as phytol (PHY) and retinol (RET), may be appropriate for cytotoxic approaches. We tested the effect of PHY or RET on the viability of human GBM cell lines (U87MG, A172 and T98G). Since the compounds showed a dose-dependent cytotoxic effect, additional analyses were performed with IC

Indexed as

Antineoplastic AgentsBiosynthetic PathwaysCell Line, TumorCell SurvivalCholesterolDose-Response Relationship, DrugFarnesyl-Diphosphate FarnesyltransferaseFatty AcidsFatty Acid SynthasesGene Expression Regulation, NeoplasticGlioblastomaHumansPhytolSterol Regulatory Element Binding Protein 1TranscriptomeVitamin AAntineoplastic AgentsCholesterolFarnesyl-Diphosphate FarnesyltransferaseFatty AcidsFatty Acid SynthasesPhytolSREBF1 protein, humanSterol Regulatory Element Binding Protein 1Vitamin AFarnesyl-diphosphate farnesyltransferaseFatty acid synthaseGlioblastomaPhytolRetinolSterol regulatory element-binding protein 1

Identifiers

PMID29159775
OpenAlexW2769873870

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.