ArticleJournal of neural transmission (Vienna, Austria : 1996)2018
Low left amygdala volume is associated with a longer duration of unipolar depression.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- Age-Related Changes in the Amygdala From In Utero to Early Childhood: Association With Social and Cognitive Outcomes.Human brain mapping · 2025Article
- Latent Profile Analysis of Childhood Maltreatment and Neural Markers in Depression.JAMA network open · 2025Article
- Alterations of amygdala volume and functional connectivity in migraine patients comorbid with and without depression.Brain and behavior · 2024Article
- Basolateral amygdala volume in affective disorders using 7T MRIFrontiers in psychiatry · 2024Article
- Serum Levels of S100B Protein and Myelin Basic Protein as a Potential Biomarkers of Recurrent Depressive Disorders.Journal of personalized medicine · 2023Article
- Atrophy in subcortical gray matter in adult patients with moyamoya disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Structural covariance network of the hippocampus-amygdala complex in medication-naïve patients with first-episode major depressive disorder.Psychoradiology · 2022Article
- Brain morphometry and connectivity differs between adolescent- and adult-onset major depressive disorder.Depression and anxiety · 2022Article
- Volume of Amygdala Subregions and Plasma Levels of Brain-Derived Neurotrophic Factor and Cortisol in Patients with s/s Genotype of Serotonin Transporter Gene Polymorphism of First-Episode and Drug-Naive Major Depressive Disorder: An Exploratory Study.Neurology international · 2022Article
- A Longitudinal Study of Medial Temporal Lobe Volumes in Graves Disease.The Journal of clinical endocrinology and metabolism · 2022Article
- Regional gray matter volume mediates the relationship between neuroticism and depressed emotion.Frontiers in psychology · 2022Article
- Psychopathological Syndromes Across Affective and Psychotic Disorders Correlate With Gray Matter Volumes.Schizophrenia bulletin · 2021Article
- Volume of Amygdala Subregions and Clinical Manifestations in Patients With First-Episode, Drug-Naïve Major Depression.Frontiers in human neuroscience · 2021Article
- Common and Specific Alterations of Amygdala Subregions in Major Depressive Disorder With and Without Anxiety: A Combined Structural and Resting-State Functional MRI Study.Frontiers in human neuroscience · 2021Article
- Structural MRI at 7T reveals amygdala nuclei and hippocampal subfield volumetric association with Major Depressive Disorder symptom severity.Scientific reports · 2019Article
- Longitudinal brain volume changes in major depressive disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2018Article
- Hippocampal and Amygdalar Volume Changes in Major Depressive Disorder: A Targeted Review and Focus on Stress.Chronic stress (Thousand Oaks, Calif.)Review
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Authors and funding
9 authors.
Funding
Abstract
The amygdala plays a crucial role in the pathogenesis of major depressive disorder (MDD). While robust findings support a negative impact of illness duration on hippocampal volume in MDD, morphometric studies of the amygdala have yielded inhomogeneous results. Considering the methodical problems of automatic segmentation methods, a standardized segmentation protocol with proven inter- and intra-rater reliability was employed using high-resolution magnetic resonance imaging. To identify the effect of MDD on amygdala morphometry, 23 unipolar depressed patients who responded to antidepressant medication and 30 age-matched healthy controls (HC) were enrolled. First, gray matter volumes (GMV) of the bilateral amygdala were delineated manually in 3D by three blinded experts using the MultiTracer. The whole brain GMV was determined by using voxel-based morphometry. Second, the differences of the whole brain and the bilateral amygdala GMV values between MDD and HC were calculated with t-statistics. The GMV of the whole brain and the amygdala did not differ between HC and MDD patients. Third, MDD characteristics were correlated with amygdala GMV. Within the normal range, the left amygdala GMV was larger in patients with later onset and smaller in cases of prolonged depression. In line with prior reports of depressed patients responding to antidepressant treatment, amygdala GMV was negatively related to illness duration, suggesting volume loss with disease progression. It remains unclear as to whether the association between illness duration and GMV reduced left amygdala volume indicates a neurotoxic effect of prolonged MDD or is rather a negative predictor of chronic depression.
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