Trial reportPflugers Archiv : European journal of physiology2018
Neuroinflammation, cortical activity, and fatiguing behaviour during self-paced exercise.
Trial report in Pflugers Archiv : European journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Acute ingestion of Ibuprofen does not influence the release of IL-6 or improve self-paced exercise in the heat despite altering cortical activity.European journal of applied physiology · 2024Article
- IL-6 signaling in acute exercise and chronic training: Potential consequences for health and athletic performance.Scandinavian journal of medicine & science in sports · 2023Review
- Acute glutamine supplementation does not improve 20-km self-paced cycling performance in the heat.European journal of applied physiology · 2019Article
- The effect of cycling in the heat on gastrointestinal-induced damage and neuromuscular fatigue.European journal of applied physiology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study aimed to identify whether or not the release of interleukin (IL)-6 and soluble (s) IL-6 receptor (R) is associated with fatiguing behaviour and changes in cortical activity during self-paced exercise. Relationships between the IL-6 and its soluble receptors, total work, reductions in power output, and changes in slow, alpha (α) and fast, beta (β) brain waves during self-paced exercise were evaluated. Different intensities and environments were used to manipulate the release of IL-6, whereby seven active males cycled for 60 min in heat stress (HS) or thermoneutral (TN) environments at a clamped rating of perceived exertion (RPE) equating to low intensity (RPE = 12) or high intensity (RPE = 16). IL-6 and sIL-6R were positively associated with total work, but not with reductions in power output. There was greater α activity in high-intensity conditions, which was associated with the reduction in power output. Both high-intensity conditions appeared to have greater β activity, and there was a positive correlation between β activity and total work and β activity and sIL-6R. We conclude that IL-6 and sIL-6R may contribute to perturbations in cortical activity and are associated with total work output, but reductions in power output are likely influenced greater by other internal and external factors.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.