Evidence map›Paper›PMID 29159521›Full record

ArticleJournal of computer-aided molecular design2017

Discovery of small molecules binding to the normal conformation of prion by combining virtual screening and multiple biological activity evaluation methods.

Lanlan Li, Wei Wei, Wen-Juan Jia, Yongchang Zhu, Yan Zhang, Jiang-Huai Chen, Jiaqi Tian, Huanxiang Liu, Yong-Xing He, Xiaojun Yao

Abstract read
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In one paragraph

Article in Journal of computer-aided molecular design, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Lanlan LiState Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou, 730000, People's Republic of China.
Wei WeiSchool of Pharmacy, Lanzhou University, Lanzhou, 730000, People's Republic of China.
Wen-Juan JiaSchool of Life Sciences, Lanzhou University, Lanzhou, 730000, People's Republic of China.
Yongchang ZhuSchool of Pharmacy, Lanzhou University, Lanzhou, 730000, People's Republic of China.
Yan ZhangState Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou, 730000, People's Republic of China.
Jiang-Huai ChenSchool of Life Sciences, Lanzhou University, Lanzhou, 730000, People's Republic of China.
Jiaqi TianSchool of Pharmacy, Lanzhou University, Lanzhou, 730000, People's Republic of China.
Huanxiang LiuSchool of Pharmacy, Lanzhou University, Lanzhou, 730000, People's Republic of China. hxliu@lzu.edu.cn.
Yong-Xing HeSchool of Life Sciences, Lanzhou University, Lanzhou, 730000, People's Republic of China. heyx@lzu.edu.cn.
Xiaojun YaoState Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou, 730000, People's Republic of China. xjyao@lzu.edu.cn.
Lanzhou University · CNMacau University of Science and Technology · MO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conformational conversion of the normal cellular prion protein, PrP

Indexed as

PrionsDrug Evaluation, PreclinicalMolecular Dynamics SimulationNeuroprotective AgentsPrion DiseasesProtein BindingProtein ConformationStructure-Activity RelationshipSurface Plasmon ResonanceNeuroprotective AgentsPrionsFibrillationFluorescence quenchingMolecular dynamics simulationPrionSurface plasmon resonanceVirtual screening

Identifiers

PMID29159521
OpenAlexW2770699611

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.