Evidence map›Paper›PMID 29159515›Full record

ArticleLasers in medical science2018

The effect of low-level laser therapy (660 nm) on the gene expression involved in tissue repair.

Stheace Kelly Fernandes Szezerbaty, Rodrigo Franco de Oliveira, Deise A A Pires-Oliveira, Cristina Pacheco Soares, Daniele Sartori, Regina Célia Poli-Frederico

Abstract read
PubMed Publisher
In one paragraph

Article in Lasers in medical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Low-level laser therapy for nipple trauma and pain during breastfeeding: systematic review and meta-analysis.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025
    Pooled it
  2. Effectiveness of Using the AOPT-LTL Technique for the Treatment of Melasma: A Clinical Study.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026
    Trial
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  6. Low-level LASER therapy accelerates fungal lesions cicatrization by increasing the production of Th1 and Th2 cytokines.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024
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  20. Muscle Recovery Is Highlighted by IR Laser Therapy.Journal of lasers in medical sciences · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Stheace Kelly Fernandes SzezerbatyDepartment of Molecular Biology, University of Northern Paraná (Unopar), Londrina, PR, Brazil.
Rodrigo Franco de OliveiraCentro Universitário de Anápolis, UniEVANGÉLICA, Anápolis, GO, Brazil.
Deise A A Pires-OliveiraCentro Universitário de Anápolis, UniEVANGÉLICA, Anápolis, GO, Brazil.
Cristina Pacheco SoaresDepartment of Cell and Tissue Biology, University of ParaíbaValley (Univap), São José dos Campos, SP, Brazil.
Daniele SartoriDepartment of Biochemistry and Biotechnology, State University of Londrina (UEL), Londrina, PR, Brazil.
Regina Célia Poli-FredericoDepartment of Cell and Molecular Biology, University of Northern Paraná (Unopar), Londrina, PR, Brazil. regina.frederico@unopar.br.ORCID http://orcid.org/0000-0003-4631-4606
Universidade Evangelica de Goiás · BRUniversidade Norte do Paraná · BRUniversidade do Vale do Paraíba · BRUniversidade Estadual de Londrina · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effect of low-level laser therapy (LLLT) on the healing of skin lesions has been evaluated in many studies; however, the molecular mechanisms involved in the biostimulatory effects resulting from this treatment need to be better understood. The paper aims to analyze the effects of LLLT (660 nm) at doses of 1 and 5 J/cm

Indexed as

Low-Level Light TherapyAnimalsCell ProliferationCell SurvivalDown-RegulationFibroblastsGene Expression RegulationInterleukin-6MiceMicroscopy, FluorescenceRNA, MessengerTime FactorsUp-RegulationVascular Endothelial Growth Factor AWound HealingInterleukin-6RNA, MessengerVascular Endothelial Growth Factor ACell viabilityIL6Low-level laser therapyTissue repairVEGF

Identifiers

PMID29159515
OpenAlexW2768332619

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.