ArticleEndoscopy international open2017
Linked color imaging (LCI), a novel image-enhanced endoscopy technology, emphasizes the color of early gastric cancer.
Article in Endoscopy international open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic accuracy of linked color imaging and white light imaging for early gastric cancer and gastrointestinal metaplasia: a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- Gel Immersion Improves Visualization in Underwater Endoscopic Mucosal Resection for Colorectal Lesions: A Prospective Crossover Trial.Journal of gastroenterology and hepatology · 2026Trial
- Diagnostic Performance of Linked Color Imaging Compared to White Light Imaging During Secondary Endoscopic Evaluation in Patients with Gastric Neoplasia Referred for Endoscopic Resection: A Randomized Comparative Study.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025Trial
- Efficacy of Texture and Color Enhancement Imaging in visualizing gastric mucosal atrophy and gastric neoplasms.Scientific reports · 2021Trial
- Article
- Diagnostic value of linked color imaging for detecting gastritis subtypes and precancerous lesions.American journal of translational research · 2026Article
- Differences in Clinical Characteristics Between Missed and Detected Laryngopharyngeal Cancers.Journal of gastroenterology and hepatology · 2025Article
- Characteristics of Superficial Gastric Neoplasms Detected Not by White Light Imaging but by Linked Color Imaging.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Linked Color Imaging with Light-Emitting Diode Light Enhances the Visibility of Gastric Neoplasm: A Prospective, Multicenter, Comparative Trial.Digestive diseases and sciences · 2025Article
- Significance of Endoscopic Redness of Duodenum in Health Checkup.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Amber-red color imaging for enhanced visualization and hemostasis during rectal endoscopic submucosal dissection.Endoscopy international open · 2025Article
- Red dichromatic imaging enhances submucosal visibility during endoscopic submucosal dissection: Pilot study.Endoscopy international open · 2025Article
- Red dichromatic imaging and linked color imaging as reliable image-enhanced endoscopic procedures for detecting the distal end of the palisade vessels in the columnar metaplastic mucosa of the gastroesophageal junction zone.Journal of gastroenterology · 2024Article
- Primary tracheal schwannoma: Bronchoscopic management of a rare tracheal tumour.Respirology case reports · 2024Article
- Higher detectability of gastric cancer afterDEN open · 2024Article
- L-Menthol for Color Difference Change Between Early Gastric Cancer and Surrounding Mucosa: A Prospective Study.Digestive diseases and sciences · 2024Article
- Comprehensive advancement in endoscopy: optical design, algorithm enhancement, and clinical validation for merged WLI and CBI imaging.Biomedical optics express · 2024Article
- Article
- Texture and color enhancement imaging improves the visibility of gastric neoplasms: clinical trial with image catalogue assessment using conventional and newly developed endoscopes.BMC gastroenterology · 2023Article
- Impact of linked color imaging and blue laser imaging on the diagnosis of esophageal squamous cell carcinoma in iodine unstained areas.The Kaohsiung journal of medical sciences · 2023Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND STUDY
aimsLinked color imaging (LCI) and blue laser imaging (BLI) are novel image-enhanced endoscopy technologies with strong, unique color enhancement. We investigated the efficacy of LCI and BLI-bright compared to conventional white light imaging (WLI) by measuring the color difference between early gastric cancer lesions and the surrounding mucosa. PATIENTS AND
methodsImages of early gastric cancer scheduled for endoscopic submucosal dissection were captured by LCI, BLI-bright, and WLI under the same conditions. Color values of the lesion and surrounding mucosa were defined as the average of the color value in each region of interest. Color differences between the lesion and surrounding mucosa (ΔE) were examined in each mode. The color value was assessed using the CIE L*a*b* color space (CIE: Commission Internationale d'Eclairage).
resultsWe collected images of 43 lesions from 42 patients. Average ΔE values with LCI, BLI-bright, and WLI were 11.02, 5.04, and 5.99, respectively. The ΔE was significantly higher with LCI than with WLI (
conclusionLCI had a larger ΔE than WLI. It may allow easy recognition and early detection of gastric cancer, even for inexperienced endoscopists.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.