ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2018
Characterizing biomarker features of cognitively normal individuals with ventriculomegaly.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Fully Automated Deep Learning-Based Pipeline for Evans Index Measurement from Raw 3D MRI.Neuroscience informatics · 2026Article
- Fully Automated Deep Learning-Based Pipeline for Evans Index Measurement from Raw 3D MRI.medRxiv : the preprint server for health sciences · 2025Article
- Dissection of Neurotropic Theiler's Murine Encephalomyelitis Virus Induced Brain Atrophy in Single MHC Class I Mice of C57BL/6 Background.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Automated magnetic resonance imaging quantification of cerebral parenchymal and ventricular volume following subarachnoid hemorrhage: associations with cognition.Brain imaging and behavior · 2024Article
- Ap4b1-knockout mouse model of hereditary spastic paraplegia type 47 displays motor dysfunction, aberrant brain morphology and ATG9A mislocalization.Brain communications · 2023Article
- Relationship between cognitive profile and neuroradiographic parameters in patients with idiopathic normal pressure hydrocephalus.Current journal of neurology · 2022Article
- Diffusion Tensor Imaging Profiles Can Distinguish Diffusivity and Neural Properties of White Matter Injury in Hydrocephalus vs. Non-hydrocephalus Using a Strategy of a Periodic Table of DTI Elements.Frontiers in neurology · 2022Article
- CSF dynamics as a predictor of cognitive progression.NeuroImage · 2021Article
- The Differential Diagnostic Value of the Callosal Angle and Evans Index in Mild Cognitive Impairment and Alzheimer's Disease.Current medical imaging · 2021Article
- The structural MRI markers and cognitive decline in prodromal Alzheimer's disease: a 2-year longitudinal study.Quantitative imaging in medicine and surgery · 2018Article
- Targeting Alzheimer's Disease at the Right Time and the Right Place: Validation of a Personalized Approach to Diagnosis and Treatment.Journal of Alzheimer's disease : JAD · 2018Review
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Authors and funding
7 authors.
Funding
Abstract
introductionThe clinical significance of ventriculomegaly in cognitively normal elderly individuals remains unclear.
methodsWe selected cognitively normal individuals (n = 425) from the Alzheimer's Disease Neuroimaging Initiative database and calculated Evans index (EI) based on the ratio of the frontal horn and skull diameter. We defined ventriculomegaly as EI ≥ 0.30, and the participants were stratified into EI ≥ 0.30 group and EI < 0.30 group. Neuropsychological, imaging, and fluid biomarker profiles between the two groups were then compared using regression models.
resultsA total of 96 (22.5%) individuals who had ventriculomegaly performed worse on the cognitive tests; showed smaller hippocampal volume but larger caudate, cingulate, and paracentral gyrus volumes; and displayed lower positron emission tomography [ DISCUSSION: Asymptomatic ventriculomegaly might be an early imaging signature of preclinical Alzheimer's disease and/or normal pressure hydrocephalus.
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