ArticleAnnals of clinical and translational neurology2017
Donepezil enhances understanding of degraded speech in Alzheimer's disease.
Article in Annals of clinical and translational neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Spore powder of Ganoderma lucidum for the treatment of Alzheimer disease: A pilot study.Medicine · 2018Trial
- Subjective time perception in dementia: a behavioural and neuroanatomical analysis.Brain communications · 2026Article
- The NeuroProtect Formula: A Preventive Approach to AD Targeting the HIF-1/PI3K-AKT Signaling Pathway Evaluated throughCombinatorial chemistry & high throughput screening · 2025Article
- Comprehension of acoustically degraded emotional prosody in Alzheimer's disease and primary progressive aphasia.Scientific reports · 2024Article
- Comprehension of acoustically degraded speech in Alzheimer's disease and primary progressive aphasia.Brain : a journal of neurology · 2023Article
- Cholinergic modulation of sensory perception and plasticity.Neuroscience and biobehavioral reviews · 2023Review
- Processing of Degraded Speech in Brain Disorders.Brain sciences · 2021Review
- Hearing and dementia: from ears to brain.Brain : a journal of neurology · 2021Review
- Primary Progressive Aphasia: Toward a Pathophysiological Synthesis.Current neurology and neuroscience reports · 2021Review
- Impairments of auditory scene analysis in posterior cortical atrophy.Brain : a journal of neurology · 2020Article
- Findings of Impaired Hearing in Patients With Nonfluent/Agrammatic Variant Primary Progressive Aphasia.JAMA neurology · 2019Article
- Retained capacity for perceptual learning of degraded speech in primary progressive aphasia and Alzheimer's disease.Alzheimer's research & therapy · 2018Article
- Commentary: Donepezil enhances understanding of degraded speech in Alzheimer's disease.Frontiers in aging neuroscience · 2018Article
- Visualizing BDNF Transcript Usage During Sound-Induced Memory Linked Plasticity.Frontiers in molecular neuroscience · 2018Article
- Sensitivity of Speech Output to Delayed Auditory Feedback in Primary Progressive Aphasias.Frontiers in neurology · 2018Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Auditory dysfunction under complex, dynamic listening conditions is a clinical hallmark of Alzheimer's disease (AD) but challenging to measure and manage. Here, we assessed understanding of sinewave speech (a paradigm of degraded speech perception) and general cognitive abilities in 17 AD patients, before and following a 10 mg dose of donepezil. Relative to healthy older individuals, patients had impaired sinewave speech comprehension that was selectively ameliorated by donepezil. Our findings demonstrate impaired perception of degraded speech in AD but retained perceptual learning capacity that can be harnessed by acetylcholinesterase inhibition, with implications for designing communication interventions and acoustic environments in dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.