ArticleJournal of clinical & translational endocrinology2014
Declining ß-cell function is associated with the lack of long-range negative correlation in glucose dynamics and increased glycemic variability: A retrospective analysis in patients with type 2 diabetes.
Article in Journal of clinical & translational endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Small changes in glucose variability induced by low and high glycemic index diets are not associated with changes in β-cell function in adults with pre-diabetes.Journal of diabetes and its complications · 2020Trial
- Improved detection of decreased glucose handling capacities via continuous glucose monitoring-derived indices.Communications medicine · 2025Article
- Continuous glucose monitoring captures glycemic variability in obesity after sleeve gastrectomy: A prospective cohort study.Obesity science & practice · 2024Article
- Reproducibility of continuous glucose monitoring results under real-life conditions in an adult population: a functional data analysis.Scientific reports · 2023Article
- Flash Glucose Monitoring to Assess Glycemic Control and Variability in Hemodialysis Patients: The GIOTTO Study.Frontiers in medicine · 2021Article
- Impact of acute-phase insulin secretion on glycemic variability in insulin-treated patients with type 2 diabetes.Endocrine · 2020Article
- Molecular Mechanisms of Glucose Fluctuations on Diabetic Complications.Frontiers in endocrinology · 2019Review
- Applications of Variability Analysis Techniques for Continuous Glucose Monitoring Derived Time Series in Diabetic Patients.Frontiers in physiology · 2018Article
- Glucose time series complexity as a predictor of type 2 diabetes.Diabetes/metabolism research and reviews · 2017Article
- Delay in the Detrended Fluctuation Analysis Crossover Point as a Risk Factor for Type 2 Diabetes Mellitus.Journal of diabetes research · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine whether characteristics of glucose dynamics are reflections of β-cell function or rather of inadequate diabetes control. MATERIALS/
methodsWe analyzed historical liquid meal tolerance test (LMTT) and continuous glucose monitoring (CGM) data, which had been obtained from 56 non-insulin treated type 2 diabetic outpatients during withdrawal of antidiabetic drugs. Computed CGM parameters included detrended fluctuation analysis (DFA)-based indices, autocorrelation function exponent, mean amplitude of glycemic excursions (MAGE), glucose SD, and measures of glycemic exposure. The LMTT-based disposition index (LMTT-DI) calculated from the ratio of the area-under-the-insulin-curve to the area-under-the-glucose-curve and Matsuda index was used to assess relationships among β-cell function, glucose profile complexity, autocorrelation function, and glycemic variability.
resultsThe LMTT-DI was inverse linearly correlated with the short-range α1 and long-range scaling exponent α2 (
conclusionsLoss of complexity and increased variability in glucose profiles are associated with declining β-cell reserve and worsening glycemic control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.