Evidence map›Paper›PMID 29159069›Full record

ArticleGenomics data2017

Co-expression network analysis identified six hub genes in association with progression and prognosis in human clear cell renal cell carcinoma (ccRCC).

Lushun Yuan, Liang Chen, Kaiyu Qian, Guofeng Qian, Chin-Lee Wu, Xinghuan Wang, Yu Xiao

Abstract read
In one paragraph

Article in Genomics data, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  14. Network Analysis of Microarray Data.Methods in molecular biology (Clifton, N.J.) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lushun YuanDepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Liang ChenDepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Kaiyu QianDepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Guofeng QianDepartment of Endocrinology, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.
Chin-Lee WuDepartment of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Xinghuan WangDepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Yu XiaoDepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human clear cell renal cell carcinoma (ccRCC) is one of the most common types of malignant adult kidney tumors. We constructed a weighted gene co-expression network to identify gene modules associated with clinical features of ccRCC (

Indexed as

ccRCC, clear cell renal cell carcinomaClear cell renal cell carcinoma (ccRCC)Co-expression network analysisDAVID, Database for Annotation, Visualization and Integrated DiscoveryDEG, differentially expressed geneDEGs, differentially expressed genesGSEA, enrichment analysis and gene set enrichmentGS, gene significanceHPA, human protein atlasHub genesMEs, module eigengenesMS, module significancePPI, protein-protein interactionPrognosisProgressionSAM, significance analysis of microarraysSTRING, search tool for the retrieval of interacting genesTCGA, the cancer genome atlasTOM, topological overlap matrixWGCNA, weighted gene co-expression network analysis

Identifiers

PMID29159069
PMCPMC5683669

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.