Evidence map›Paper›PMID 29159046›Full record

ArticleNeuroImage. Clinical2018

Imaging of glia activation in people with primary lateral sclerosis.

Sabrina Paganoni, Mohamad J Alshikho, Nicole R Zürcher, Paul Cernasov, Suma Babu, Marco L Loggia, James Chan, Daniel B Chonde, David Izquierdo Garcia, Ciprian Catana and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 35 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Cell type-specific gene therapy confers protection against motor neuron disease caused by a TFG variant.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Article
  7. Neuroimmune signatures in chronic low back pain subtypes.Brain : a journal of neurology · 2022
    Article
  8. Review
  9. [Molecular psychiatry · 2021
    Article
  10. Review
  11. Measuring disease progression in primary lateral sclerosis.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2020
    Article
  12. Review
  13. Better understanding the neurobiology of primary lateral sclerosis.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2020
    Review
  14. Clinical care and therapeutic trials in PLS.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2020
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Sabrina PaganoniHarvard Medical School, Department of Neurology, Neurological Clinical Research Institute (NCRI), Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Charlestown, MA, USA. Electronic address: spaganoni@mgh.harvard.edu.
Mohamad J AlshikhoHarvard Medical School, Department of Neurology, Neurological Clinical Research Institute (NCRI), Massachusetts General Hospital, Boston, MA, USA; A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. Electronic address: malshikho@mgh.harvard.edu.
Nicole R ZürcherA. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. Electronic address: zurcher@nmr.mgh.harvard.edu.
Paul CernasovHarvard Medical School, Department of Neurology, Neurological Clinical Research Institute (NCRI), Massachusetts General Hospital, Boston, MA, USA. Electronic address: paul.cernasov@gmail.com.
Suma BabuHarvard Medical School, Department of Neurology, Neurological Clinical Research Institute (NCRI), Massachusetts General Hospital, Boston, MA, USA. Electronic address: sbabu@mgh.harvard.edu.
Marco L LoggiaA. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. Electronic address: marco@nmr.mgh.harvard.edu.
James ChanBiostatistics Center, Massachusetts General Hospital, Boston, MA, USA. Electronic address: jchan12@mgh.harvard.edu.
Daniel B ChondeA. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. Electronic address: chonde@mit.edu.
David Izquierdo GarciaA. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. Electronic address: davidizq@nmr.mgh.harvard.edu.
Ciprian CatanaA. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. Electronic address: ccatana@nmr.mgh.harvard.edu.
Caterina MaineroA. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. Electronic address: caterina@nmr.mgh.harvard.edu.
Bruce R RosenA. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. Electronic address: bruce@nmr.mgh.harvard.edu.
Merit E CudkowiczHarvard Medical School, Department of Neurology, Neurological Clinical Research Institute (NCRI), Massachusetts General Hospital, Boston, MA, USA. Electronic address: mcudkowicz@mgh.harvard.edu.
Jacob M HookerA. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. Electronic address: hooker@nmr.mgh.harvard.edu.
Nazem AtassiHarvard Medical School, Department of Neurology, Neurological Clinical Research Institute (NCRI), Massachusetts General Hospital, Boston, MA, USA. Electronic address: natassi@mgh.harvard.edu.
Harvard University · USMassachusetts General Hospital · US

Funding

MR-assisted PET data optimization for neuroimaging studiesR01EB014894 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI CATANA, CIPRIAN · 2013 to 2016
$2.6M
Molecular Imaging of Inflammation in Amyotrophic Lateral Sclerosis (ALS)K23NS083715 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ATASSI, NAZEM · 2014 to 2018
$927k
NIBIB NIH HHS R01 EB014894NINDS NIH HHS K23 NS083715
6 · The paper itself

Abstract

backgroundGlia activation is thought to contribute to neuronal damage in several neurodegenerative diseases based on preclinical and human

objectivesTo localize and measure glia activation in people with PLS compared to healthy controls (HC).

methodsTen participants with PLS and ten age-matched HCs underwent simultaneous magnetic resonance (MR) and proton emission tomography (PET). The radiotracer [

resultsPET data showed increased [

conclusionsThis study supports a link between glia activation and neuronal degeneration in PLS, and suggests that these disease mechanisms can be measured

Indexed as

AdultAgedBrainCarbon RadioisotopesDiffusion Magnetic Resonance ImagingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMotor Neuron DiseaseNeurogliaPositron-Emission TomographyReceptors, GABAWhite MatterCarbon RadioisotopesReceptors, GABATSPO protein, human[11C]-PBR28Amyotrophic lateral sclerosisDiffusionPETPrimary lateral sclerosisTSPO

Identifiers

PMID29159046
PMCPMC5681341
OpenAlexW2767110945

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.