Evidence map›Paper›PMID 29159039›Full record

ArticleNeuroImage. Clinical2018

Disruption of default mode network dynamics in acute and chronic pain states.

Z Alshelh, K K Marciszewski, R Akhter, F Di Pietro, E P Mills, E R Vickers, C C Peck, G M Murray, L A Henderson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Z AlshelhDepartment of Anatomy and Histology, University of Sydney, 2006, Australia.
K K MarciszewskiDepartment of Anatomy and Histology, University of Sydney, 2006, Australia.
R AkhterFaculty of Dentistry, University of Sydney, 2006, Australia.
F Di PietroDepartment of Anatomy and Histology, University of Sydney, 2006, Australia.
E P MillsDepartment of Anatomy and Histology, University of Sydney, 2006, Australia.
E R VickersDepartment of Anatomy and Histology, University of Sydney, 2006, Australia.
C C PeckFaculty of Dentistry, University of Sydney, 2006, Australia.
G M MurrayFaculty of Dentistry, University of Sydney, 2006, Australia.
L A HendersonDepartment of Anatomy and Histology, University of Sydney, 2006, Australia. Electronic address: lukeh@anatomy.usyd.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has been proposed that pain competes with other attention-demanding stimuli for cognitive resources, and many chronic pain patients display significant attention and mental flexibility deficits. These alterations may result from disruptions in the functioning of the default mode network (DMN) which plays a critical role in attention, memory, prospection and self-processing, and recent investigations have found alterations in DMN function in multiple chronic pain conditions. Whilst it has been proposed that these DMN alterations are a characteristic of pain that is chronic in nature, we recently reported altered oscillatory activity in the DMN during an acute, 5  minute noxious stimulus in healthy control subjects. We therefore hypothesize that altered DMN activity patterns will not be restricted to those in chronic pain but instead will also occur in healthy individuals during tonic noxious stimuli. We used functional magnetic resonance imaging to measure resting state infra-slow oscillatory activity and functional connectivity in patients with chronic orofacial pain at rest and in healthy controls during a 20-minute tonic pain stimulus. We found decreases in oscillatory activity in key regions of the DMN in patients with chronic pain, as well as in healthy controls during tonic pain in addition to changes in functional connectivity between the posterior cingulate cortex and areas of the DMN in both groups. The results show that similar alterations in DMN function occur in healthy individuals during acute noxious stimuli as well as in individuals with chronic pain. These DMN changes may reflect the presence of pain per se and may underlie alterations in attentional processes that occur in the presence of pain.

Indexed as

Acute PainAdultAttentionBrainBrain MappingChronic PainFacial PainFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeural PathwaysALFF, amplitude of low-frequency fluctuationsAttentionChronic orofacial painDMN, default mode networkfALFF, fractional amplitude of low-frequency fluctuationsFunctional magnetic resonance imagingIPC, inferior parietal cortexISO, infra-slow oscillationsmPFC, medial prefrontal cortexPCC, posterior cingulate cortexPosterior cingulate cortexPrecuneusPrefrontal cortex

Identifiers

PMID29159039
PMCPMC5683191

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.