Evidence map›Paper›PMID 29158882›Full record

ArticleBasic and clinical neuroscience

The Mediating Role of A

Masoomeh Bakhshayesh, Fereshteh Golab, Fatemeh Kermanian, Mehdi Mehdizadeh, Amir Reza Katebi, Mansooreh Soleimani, Farzaneh Mohammadzadeh, Ronak Shabani, Elham Movahed, Majid Katebi

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Basic and clinical neuroscience. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Masoomeh BakhshayeshCellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
Fereshteh GolabCellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
Fatemeh KermanianDepartment of Anatomy, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
Mehdi MehdizadehCellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
Amir Reza KatebiDepartment of Educational Psychology, Faculty of Psychology & Educational Sciences, Allameh Tabataba'i University, Tehran, Iran.
Mansooreh SoleimaniCellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
Farzaneh MohammadzadehDepartment of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Ronak ShabaniCellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
Elham MovahedDepartment of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Majid KatebiCellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
Iran University of Medical Sciences · IRHormozgan University of Medical Sciences · IRJahrom University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) is a popular recreational drug and a major source of substance abuse, which ultimately leads to sensations of well-being, elation and euphoria, moderate derealization/depersonalization, and cognitive disruptions, as well as intense sensory awareness. The mechanisms involved in memory impairment induced by MDMA are not completely understood.

methodsThe current study used 40 Sprague-Dawley rats, weighted 200 to 250 g. Experiments were performed in four groups, each containing 10 rats. The first group of rats was used as the control, treated with dimethyl sulfoxide (DMSO). The second group was treated with MDMA. The third group was treated with MDMA and CGS (the adenosine A

resultsIt was observed that the coadministration of MDMA with CGS reduced bax expression and prevented apoptosis of hippocampal cells. The coadministration of MDMA and SCH increased bax expression, and also increased the frequency of hippocampal cell apoptosis.

conclusionThe results of the current study showed that administration of CGS with MDMA decreased the common side effects associated with MDMA.

Indexed as

Adenosine receptorAgonist of A2A receptorAntagonist of A2A receptorEcstasy or MDMANeurotoxicity

Identifiers

PMID29158882
PMCPMC5683689
OpenAlexW2752635665

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.