Evidence map›Paper›PMID 29158842›Full record

ArticleTheranostics2017

Locoregional Confinement and Major Clinical Benefit of

Delphine Séhédic, Igor Chourpa, Clément Tétaud, Audrey Griveau, Claire Loussouarn, Sylvie Avril, Claire Legendre, Nicolas Lepareur, Didier Wion, François Hindré and 2 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 62 citations in OpenAlex.

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  15. Article
  16. Novel Strategies for Nanoparticle-Based Radiosensitization in Glioblastoma.International journal of molecular sciences · 2021
    Review
  17. Review
  18. Review
  19. Frontiers in oncology · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Delphine SéhédicCRCINA, INSERM, Université de Nantes, Université d'Angers, 49933 Angers, France.
Igor ChourpaUniversité Tours, EA6295, "Nanomédicaments et Nanosondes", 37020 Tours, France.
Clément TétaudCRCINA, INSERM, Université de Nantes, Université d'Angers, 49933 Angers, France.
Audrey GriveauCRCINA, INSERM, Université de Nantes, Université d'Angers, 49933 Angers, France.
Claire LoussouarnCRCINA, INSERM, Université de Nantes, Université d'Angers, 49933 Angers, France.
Sylvie AvrilCRCINA, INSERM, Université de Nantes, Université d'Angers, 49933 Angers, France.
Claire LegendreCRCINA, INSERM, Université de Nantes, Université d'Angers, 49933 Angers, France.
Nicolas LepareurCentre Regional de Lutte Contre le Cancer Eugène Marquis, Department of Nuclear Medicine, 35042 Rennes, France.
Didier WionINSERM U1205, bâtiment modulaire 40-23, CEA 17 rue des Martyrs, 38054 Grenoble cedex, France.
François HindréCRCINA, INSERM, Université de Nantes, Université d'Angers, 49933 Angers, France.
François DavodeauCRCINA, INSERM, Université d'Angers, Université de Nantes, 44035 Nantes, France.
Emmanuel GarcionCRCINA, INSERM, Université de Nantes, Université d'Angers, 49933 Angers, France.
Inserm · FRNantes Université · FRCentre Eugène Marquis · FRUniversité d'Angers · FRUniversité de Tours · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeGold standard beam radiation for glioblastoma (GBM) treatment is challenged by resistance phenomena occurring in cellular populations well prepared to survive or to repair damage caused by radiation. Among signals that have been linked with radio-resistance, the SDF1/CXCR4 axis, associated with cancer stem-like cell, may be an opportune target. To avoid the problem of systemic toxicity and blood-brain barrier crossing, the relevance and efficacy of an original system of local brain internal radiation therapy combining a radiopharmaceutical with an immuno-nanoparticle was investigated. EXPERIMENT

designThe nanocarrier combined lipophilic thiobenzoate complexes of rhenium-188 loaded in the core of a lipid nanocapsule (LNC

resultsWe demonstrated that 12G5-LNC

Indexed as

AnimalsBlood-Brain BarrierBrainBrain NeoplasmsCell Line, TumorDisease Models, AnimalFemaleGlioblastomaHumansLipidsMiceNanocapsulesNanoparticlesNeoplastic Stem CellsRadioisotopesRadiopharmaceuticalsCXCR4 protein, humanLipidsNanocapsulesRadioisotopesRadiopharmaceuticalsReceptors, CXCR4RheniumRhenium-188CXCR4, glioblastoma, radiation therapy, immuno-targeting, spectral imaging, macrophagenanoparticle.

Identifiers

PMID29158842
PMCPMC5695146
OpenAlexW2765365890

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.