Evidence map›Paper›PMID 29158830›Full record

ArticleTheranostics2017

Sustained Release Talazoparib Implants for Localized Treatment of

Jodi E Belz, Rajiv Kumar, Paige Baldwin, Noelle Castilla Ojo, Ana S Leal, Darlene B Royce, Di Zhang, Anne L van de Ven, Karen T Liby, Srinivas Sridhar

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

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  12. Metastasis and cachexia: alongside in clinics, but not so in animal models.Journal of cachexia, sarcopenia and muscle · 2019
    Review
  13. Article
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  16. Nanomedicine Therapies for Pediatric Diseases.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jodi E BelzNortheastern University, Department of Bioengineering, Boston, MA.
Rajiv KumarNanomedicine Science and Technology Center, Northeastern University, Boston, MA.
Paige BaldwinNortheastern University, Department of Bioengineering, Boston, MA.
Noelle Castilla OjoNanomedicine Science and Technology Center, Northeastern University, Boston, MA.
Ana S LealGeisel School of Medicine at Dartmouth, Department of Pharmacology, Hanover, NH.
Darlene B RoyceGeisel School of Medicine at Dartmouth, Department of Pharmacology, Hanover, NH.
Di ZhangGeisel School of Medicine at Dartmouth, Department of Pharmacology, Hanover, NH.
Anne L van de VenNanomedicine Science and Technology Center, Northeastern University, Boston, MA.
Karen T LibyGeisel School of Medicine at Dartmouth, Department of Pharmacology, Hanover, NH.
Srinivas SridharNanomedicine Science and Technology Center, Northeastern University, Boston, MA.
Northeastern University · USDartmouth College · US

Funding

CaNCURE: Cancer Nanomedicine Co-ops For Undergraduate Research ExperiencesR25CA174650 · NCI · NORTHEASTERN UNIVERSITY · PI SRINIVAS SRIDHAR · 2014 to 2026
$3.4M
Integrative Training in the Pharmacological SciencesT32GM092715 · NIGMS · MICHIGAN STATE UNIVERSITY · PI NEUBIG, RICHARD R · 2011 to 2020
$1.5M
NCI NIH HHS R25 CA174650NIGMS NIH HHS T32 GM092715
6 · The paper itself

Abstract

Talazoparib, a potent PARP inhibitor, has shown promising clinical and pre-clinical activity by inducing synthetic lethality in cancers with germline

Indexed as

AnimalsBRCA1 ProteinBreast NeoplasmsCell Line, TumorFemaleLactic AcidMiceMicroscopy, Electron, ScanningPhthalazinesPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerXenograft Model Antitumor AssaysBRCA1 ProteinBRCA1 protein, humanLactic AcidPhthalazinesPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymertalazoparibBRCA-1breast cancerlocal therapyPARP inhibitorsustained delivery.Talazoparib

Identifiers

PMID29158830
PMCPMC5695017
OpenAlexW2765361350

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.