Evidence map›Paper›PMID 29158814›Full record

ArticleTheranostics2017

DNA Methylation of miR-7 is a Mechanism Involved in Platinum Response through

Olga Vera, Julia Jimenez, Olga Pernia, Carlos Rodriguez-Antolin, Carmen Rodriguez, Fatima Sanchez Cabo, Javier Soto, Rocio Rosas, Sara Lopez-Magallon, Isabel Esteban Rodriguez and 9 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 2 countries.

Olga VeraCancer Epigenetics Laboratory, INGEMM, La Paz University Hospital, Madrid, Spain.
Julia JimenezCancer Epigenetics Laboratory, INGEMM, La Paz University Hospital, Madrid, Spain.
Olga PerniaCancer Epigenetics Laboratory, INGEMM, La Paz University Hospital, Madrid, Spain.
Carlos Rodriguez-AntolinCancer Epigenetics Laboratory, INGEMM, La Paz University Hospital, Madrid, Spain.
Carmen RodriguezCancer Epigenetics Laboratory, INGEMM, La Paz University Hospital, Madrid, Spain.
Fatima Sanchez CaboBioinformatics Unit, Centro Nacional de Investigaciones Cardiovasculares Madrid, Spain.
Javier SotoCancer Epigenetics Laboratory, INGEMM, La Paz University Hospital, Madrid, Spain.
Rocio RosasCancer Epigenetics Laboratory, INGEMM, La Paz University Hospital, Madrid, Spain.
Sara Lopez-MagallonDepartment of Obstetrics and Gynecology, La Paz University Hospital, Madrid, Spain.
Isabel Esteban RodriguezBiomarkers and Experimental Therapeutics in Cancer, IdiPAZ, Madrid, Spain.
Ana DopazoGenomics Unit, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.
Federico RojoDepartment of Pathology, University Hospital Fundación Jiménez Díaz, Madrid, Spain.
Cristobal BeldaDepartment of Oncology, HM Hospitales, Madrid, Spain.
Rafael AlvarezDepartment of Oncology, HM Hospitales, Madrid, Spain.
Jaime ValentinTranslational Research in pediatric oncology Hematopoietic transplantation and cell Therapy, IdiPAZ, Madrid, Spain.
Javier BenitezHuman Genetics Group, Spanish National Cancer Research Center (CNIO).
Rosario PeronaBiomarkers and Experimental Therapeutics in Cancer, IdiPAZ, Madrid, Spain.
Javier De CastroBiomarkers and Experimental Therapeutics in Cancer, IdiPAZ, Madrid, Spain.
Inmaculada Ibanez de CaceresCancer Epigenetics Laboratory, INGEMM, La Paz University Hospital, Madrid, Spain.
Hospital Universitario La Paz · ESHospital La Paz Institute for Health Research · ESHM Hospitales · ESSpanish National Centre for Cardiovascular Research · ESCancer Research Center · USHospital Universitario Fundación Jiménez Díaz · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the major limitations associated with platinum use is the resistance that almost invariably develops in different tumor types. In the current study, we sought to identify epigenetically regulated microRNAs as novel biomarkers of platinum resistance in lung and ovarian cancers, the ones with highest ratios of associated chemo-resistance.

Indexed as

AdolescentAdultAgedAged, 80 and overAntineoplastic AgentsCell Line, TumorCisplatinDNA MethylationDrug Resistance, NeoplasmEpigenesis, GeneticFemaleGene Expression Regulation, NeoplasticHumansMafG Transcription FactorMicroRNAsMiddle AgedAntineoplastic AgentsCisplatinMAFG protein, humanMafG Transcription FactorMicroRNAsMIRN7-1 microRNA, humanRepressor Proteinscancer.Cisplatin-resistanceDNA methylationMAFGmiR-7

Identifiers

PMID29158814
PMCPMC5695001
OpenAlexW2766451867

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.