ArticleSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society2017
Adverse drug reactions in high-risk pregnant women: A prospective study.
Article in Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Prevalence of clinically manifested drug interactions in hospitalized patients: A systematic review and meta-analysis.PloS one · 2020Pooled it
- Mortality among patients due to adverse drug reactions that occur following hospitalisation: a meta-analysis.European journal of clinical pharmacology · 2019Pooled it
- Magnitude, Preventability, and Determinants of Adverse Drug Reactions Among Hospitalized Obstetric Patients in Ethiopia: A Prospective Observational Study.Pharmacology research & perspectives · 2026Observational
- Predicting DDI-induced pregnancy and neonatal ADRs using sparse PCA and stacking ensemble approach.Journal of integrative bioinformatics · 2025Article
- Adverse Drug Reactions in Pregnant People with Hypertension and/or Diabetes: Temporal Profile and Associated Factors.The Canadian journal of hospital pharmacy · 2025Article
- A Narrative Review of Adverse Event Detection, Monitoring, and Prevention in Indian Hospitals.Cureus · 2022Review
- Incidence of Adverse Drug Reactions in High-Risk Pregnancy: A Prospective Cohort Study in Obstetric Intensive Care.European journal of clinical pharmacology · 2020Observational
- Prevalence and profile of adverse drug reactions in high-risk pregnancy: a cohort study.BMC pregnancy and childbirth · 2019Observational
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBecause pregnant women are often excluded from clinical trials, there is still very limited information about the risk and safety of prescription drugs during pregnancy.
objectiveWe aimed to determine the prevalence of Adverse Drug Reactions (ADRs) in high-risk pregnant women after hospital admission. A prospective study was carried out in a teaching maternity hospital in Brazil during six months. Causality of ADRs was assessed through the Naranjo Algorithm and Korean Algorithm for ADR Causality Assessment. Severity of ADRs was assessed using Hartwig's Severity Assessment Scale.
resultsThe prevalence of ADRs among the 294 inpatients studied was 8.8%. The mean age was 27.14 (±7.5) y.o. Patient's age was related to the presence of ADRs, while the manifestation of these events was not associated with any adverse pregnancy outcome. 75.9% of the ADRs reported in the study were of mild severity and 24.1% were of moderate severity. No ADR was caused by drug-drug interaction; however, a significant increase in blood pressure was observed in all patients using concurrent methyldopa and ferrous sulfate.
conclusionOverall, ADRs were not common events among high-risk pregnant women and no adverse pregnancy outcomes following these events were observed.
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Registered trials
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