Evidence map›Paper›PMID 29158583›Full record

ArticleMolecular psychiatry2018

Patient-derived iPSCs show premature neural differentiation and neuron type-specific phenotypes relevant to neurodevelopment.

E Yeh, D Q Dao, Z Y Wu, S M Kandalam, F M Camacho, C Tom, W Zhang, R Krencik, K A Rauen, E M Ullian and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
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  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Cellular Models in Schizophrenia Research.International journal of molecular sciences · 2021
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

E YehDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.
D Q DaoDepartment of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA.
Z Y WuDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.
S M KandalamDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.
F M CamachoDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.
C TomDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.
W ZhangDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.
R KrencikDepartment of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA.
K A RauenDepartment of Pediatrics, University of California, Davis, Sacramento, CA, USA.
E M UllianDepartment of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA.
L A WeissDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA, USA. lauren.weiss@ucsf.edu.

Funding

Training Program for the Visual SciencesT32EY007120 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COPENHAGEN, DAVID RICHARD · 1990 to 2015
$2.9M
Dissecting Epistasis and Pleiotropy in Autism towards Personalized MedicineDP2OD007449 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WEISS, LAUREN ANNE · 2010 to 2014
$2.4M
The Role of Germline Mutations of the Ras/MAPK Pathway on Skeletal MyogenesisR01AR062165 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RAUEN, KATHERINE ANNA · 2012 to 2017
$2.1M
NIAMS NIH HHS R01 AR062165NIH HHS DP2 OD007449
6 · The paper itself

Abstract

Ras/MAPK pathway signaling is a major participant in neurodevelopment, and evidence suggests that BRAF, a key Ras signal mediator, influences human behavior. We studied the role of the mutation BRAF

Indexed as

MAP Kinase Signaling SystemCell Culture TechniquesEctodermal DysplasiaFaciesFailure to ThriveHeart Defects, CongenitalHumansInduced Pluripotent Stem CellsMutationNeurogenesisNeuronsPhenotypePhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-aktBRAF protein, humanPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-akt

Identifiers

PMID29158583
PMCPMC5962360

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.