ArticleInternational journal of obesity (2005)2018
Genetic predisposition to obesity, restrained eating and changes in body weight: a population-based prospective study.
Article in International journal of obesity (2005), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- A plasma metabolite score of three eicosanoids predicts incident type 2 diabetes: a prospective study in three independent cohorts.BMJ open diabetes research & care · 2022Pooled it
- Exploring the relations between body dissatisfaction, rumination, physical activity, and restrained eating: a latent moderated structural equation approach.Journal of eating disorders · 2025Article
- Association between healthy neuroticism and eating behavior as revealed by the NKI Rockland Sample.Scientific reports · 2025Article
- Association between DASH diet and metabolic syndrome in US adults: a cross-sectional study.Frontiers in public health · 2025Article
- Mediation and moderation of genetic risk of obesity through eating behaviours in two UK cohorts.International journal of epidemiology · 2023Article
- Associations of food motives with red meat and legume consumption in the population-based DILGOM study.European journal of nutrition · 2023Article
- Emotional Eating as a Mediator in the Relationship between Dietary Restraint and Body Weight.Nutrients · 2023Article
- Snacking and anxiety during the coronavirus disease (COVID-19) pandemic: A prospective cohort study.Appetite · 2023Article
- Identification of several eating habits that mediate the association between eating behaviors and the risk of obesity.Obesity science & practice · 2022Article
- Validation of the Flexible and Rigid Cognitive Restraint Scales in a General French Population.International journal of environmental research and public health · 2022Article
- Comprehensive biomarker profiling of hypertension in 36 985 Finnish individuals.Journal of hypertension · 2022Article
- The temporal relationship between parental concern of overeating and childhood obesity considering genetic susceptibility: longitudinal results from the IDEFICS/I.Family study.The international journal of behavioral nutrition and physical activity · 2021Article
- The Relationship between Restrained Eating, Body Image, and Dietary Intake among University Students in China: A Cross-Sectional Study.Nutrients · 2021Article
- The Role of Eating Behaviours in Genetic Susceptibility to Obesity.Current obesity reports · 2020Review
- The genetic architecture of the association between eating behaviors and obesity: combining genetic twin modeling and polygenic risk scores.The American journal of clinical nutrition · 2020Article
- A cross-omics integrative study of metabolic signatures of chronic obstructive pulmonary disease.BMC pulmonary medicine · 2020Article
- Eating behavior and metabolic syndrome over time.Eating and weight disorders : EWD · 2020Article
- The Association Between Salivary Ghrelin Levels with Anthropometric Measures in Underweight, Normal, Overweight and Obese Healthy Adult Males.European endocrinology · 2020Article
- Association between post-cessation weight gain and eating behavior changes.Northern clinics of Istanbul · 2020Article
- Salivary Cytokine Biomarker Concentrations in Relation to Obesity and Periodontitis.Journal of clinical medicine · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThere is no consensus on whether cognitive control over food intake (that is, restrained eating) is helpful, merely ineffective or actually harmful in weight management. We examined the interplay between genetic risk of obesity, restrained eating and changes in body weight and size.
methodsParticipants were Finnish aged 25-74 years who attended the DIetary, Lifestyle and Genetic determinants of Obesity and Metabolic syndrome study at baseline in 2007 and follow-up in 2014. At baseline (n=5024), height, weight and waist circumference (WC) were measured in a health examination and participants self-reported their weight at age 20 years. At follow-up (n=3735), height, weight and WC were based on measured or self-reported information. We calculated 7-year change in body mass index (BMI) and WC and annual weight change from age 20 years to baseline. Three-Factor Eating Questionnaire-R18 was used to assess restrained eating. Genetic risk of obesity was assessed by calculating a polygenic risk score of 97 known BMI-related loci.
resultsCross-lagged autoregressive models indicated that baseline restrained eating was unrelated to 7-year change in BMI (β=0.00; 95% confidence interval (CI)=-0.01, 0.02). Instead, higher baseline BMI predicted greater 7-year increases in restrained eating (β=0.08; 95% CI=0.05, 0.11). Similar results were obtained with WC. Polygenic risk score correlated positively with restrained eating and obesity indicators in both study phases, but it did not predict 7-year change in BMI or WC. However, individuals with higher genetic risk of obesity tended to gain more weight from age 20 years to baseline, and this association was more pronounced in unrestrained eaters than in restrained eaters (P=0.038 for interaction).
conclusionsOur results suggest that restrained eating is a marker for previous weight gain rather than a factor that leads to future weight gain in middle-aged adults. Genetic influences on weight gain from early to middle adulthood may vary according to restrained eating, but this finding needs to be replicated in future studies.
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