Evidence map›Paper›PMID 29158528›Full record

ArticleScientific reports2017

Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection.

Hailiang Huang, Priya Duggal, Chloe L Thio, Rachel Latanich, James J Goedert, Alessandra Mangia, Andrea L Cox, Gregory D Kirk, Shruti Mehta, Jasneet Aneja and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 14 institutions in 4 countries.

Hailiang HuangAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, 02114, USA.ORCID 0000-0003-1461-5762
Priya DuggalJohns Hopkins University Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
Chloe L ThioJohns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Rachel LatanichJohns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
James J GoedertDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, 20852, USA.
Alessandra MangiaIRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy.
Andrea L CoxJohns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Gregory D KirkJohns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Shruti MehtaJohns Hopkins University Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
Jasneet AnejaDepartment of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Laurent AlricDepartment of Medicine, Purpan Hospital, University of Toulouse III, Toulouse, France.
Sharyne M DonfieldRho, Chapel Hill, NC, 27517, USA.
Matthew E CrampSouth West Liver Unit, Plymouth Hospitals NHS Trust, Plymouth, United Kingdom.
Salim I KhakooHenry Welcome Laboratories, Southampton General Hospital, Southampton, UK.ORCID 0000-0002-4057-9091
Leslie H ToblerUniversity of California and Blood Systems Research Institute, San Francisco, CA, 94118, USA.
Michael BuschUniversity of California and Blood Systems Research Institute, San Francisco, CA, 94118, USA.
Graeme J AlexanderCambridge University Hospitals NHS Foundation Trust and Addenbrooke's Hospital, Cambridge, United Kingdom.
Hugo R RosenUniversity of Colorado, Aurora, Colorado, 90045, United States.
Brian R EdlinState University of New York Downstate College of Medicine, Brooklyn, New York, USA.
Florencia P SegalBrigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Georg M LauerDepartment of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
David L ThomasJohns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Mark J DalyAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, 02114, USA.
Raymond T ChungDepartment of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. rtchung@partners.org.
Arthur Y KimDepartment of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. AKIM1@mgh.harvard.edu.
Johns Hopkins University · USHarvard University · USBlood Systems Research Institute · USBroad Institute · USBrigham and Women's Hospital · USCambridge University Hospitals NHS Foundation Trust · GBCasa Sollievo della Sofferenza · ITNational Cancer Institute · USPlymouth Hospital · GBRho (United States) · USSouthampton General Hospital · GBState University of New York · USUniversité Toulouse III - Paul Sabatier · FRUniversity of Colorado Anschutz Medical Campus · US

Funding

Disparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2M
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
NATURAL HISTORY OF AIDS IN HOMOSEXUAL MENU01AI035040 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DETELS, ROGER, MARTINEZ-MAZA, OTONIEL · 1993 to 2018
$75.2M
University of Pittsburgh Multicenter AIDS Cohort Study (MACS)U01AI035041 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARTINSON, JEREMY JAMES, RINALDO, CHARLES R · 1993 to 2018
$71.4M
MULTICENTER AIDS COHORT STUDYU01AI035039 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOLINSKY, STEVEN M · 1993 to 2018
$66.4M
Multicenter Aids Cohort Study- Part B (Baltimore Site)U01AI035042 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BROWN, TODD T, MARGOLICK, JOSEPH B. · 1993 to 2018
$61.5M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024996 · NCRR · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2007 to 2011
$49.6M
Virology CoreU19AI082630 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI GEORG Michael LAUER · 2009 to 2026
$48.1M
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 1991 to 2026
$35.3M
METHODOLOGICAL EXPERTISE IN INTREPRETING MACS DATAU01AI035043 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JACOBSON, LISA P · 1993 to 2011
$26.9M
Center for the Analysis & Management of the Multicenter AIDS Cohort StudyUM1AI035043 · NIAID · JOHNS HOPKINS UNIVERSITY · PI D'SOUZA, GYPSYAMBER, JACOBSON, LISA P · 2012 to 2018
$20.7M
INCIDENCE OF HIV INFECTIONS IN A COHORT OF IV DRUG USERSR01DA012568 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MEHTA, SHRUTI H · 1999 to 2017
$15.5M
Medical Research Council G1001738Medical Research Council MR/M019829/1NCATS NIH HHS UL1 TR002384NCRR NIH HHS UL1 RR024996NCRR NIH HHS UL1 RR025005NHLBI NIH HHS R01 HL076902NIAID NIH HHS U01 AI035039NIAID NIH HHS U01 AI035040NIAID NIH HHS U01 AI035041NIAID NIH HHS U01 AI035042NIAID NIH HHS U01 AI035043NIAID NIH HHS U19 AI082630NIAID NIH HHS U19 AI088791NIAID NIH HHS UM1 AI035043NICHD NIH HHS R01 HD041224NIDA NIH HHS R01 DA004334NIDA NIH HHS R01 DA012568NIDA NIH HHS R01 DA013324NIDA NIH HHS R01 DA016159NIDA NIH HHS R01 DA021550NIDA NIH HHS R01 DA033541NIDDK NIH HHS K01 DK114379NIDDK NIH HHS P30 DK043351
6 · The paper itself

Abstract

Approximately three quarters of acute hepatitis C (HCV) infections evolve to a chronic state, while one quarter are spontaneously cleared. Genetic predispositions strongly contribute to the development of chronicity. We have conducted a genome-wide association study to identify genomic variants underlying HCV spontaneous clearance using ImmunoChip in European and African ancestries. We confirmed two previously reported significant associations, in the IL28B/IFNL4 and the major histocompatibility complex (MHC) regions, with spontaneous clearance in the European population. We further fine-mapped the association in the MHC to a region of about 50 kilo base pairs, down from 1 mega base pairs in the previous study. Additional analyses suggested that the association in MHC is stronger in samples from North America than those from Europe.

Indexed as

Genetic Predisposition to DiseaseEuropeFemaleGenome-Wide Association StudyGenotypeHepacivirusHepatitis CHumansInterferon LambdaInterferonsInterleukinsMajor Histocompatibility ComplexMaleNorth AmericaPolymorphism, Single NucleotideIFNL4 protein, humanInterferon Lambdainterferon-lambda, humanInterferonsInterleukins

Identifiers

PMID29158528
PMCPMC5696522
OpenAlexW2952740807

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.