ArticleNature communications2017
A programmed cell division delay preserves genome integrity during natural genetic transformation in Streptococcus pneumoniae.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 58 citations in OpenAlex.
- A synopsis of competence-regulated virulence inVirulence · 2026Review
- LytF contributes to pilus extrusion during natural competence inJournal of bacteriology · 2026Article
- Genomic and functional dissection of natural transformation-related genes inMicrobiology spectrum · 2026Article
- Characterisation of the NovelInternational journal of molecular sciences · 2025Article
- A toxin/antitoxin system targeting the replication sliding-clamp induces competence in Streptococcus pneumoniae.PLoS genetics · 2025Article
- LytF contributes to pilus extrusion during natural competence inbioRxiv : the preprint server for biology · 2025Article
- ComK-induced cell death is reversed by upregulating the SigB or Spx pathway inMicrobiology spectrum · 2025Article
- Transient inhibition of cell division in competent pneumococcal cells results from deceleration of the septal peptidoglycan complex.Nature communications · 2025Article
- A roadmap to understanding and anticipating microbial gene transfer in soil communities.Microbiology and molecular biology reviews : MMBR · 2025Review
- An atlas of bacterial serine-threonine kinases reveals functional diversity and key distinctions from eukaryotic kinases.Science signaling · 2025Article
- Structure, Function, and Regulation of LytA: TheMicroorganisms · 2025Review
- Article
- Competence Regulation inCurrent medicinal chemistry · 2025Review
- Comparative analysis of theFrontiers in microbiology · 2025Article
- Pneumococcal competence is a populational health sensor driving multilevel heterogeneity in response to antibiotics.Nature communications · 2024Article
- The ComRS-SigX Pathway Regulates Natural Transformation in Streptococcus ferus.Journal of bacteriology · 2023Article
- Article
- The ComRS-SigX pathway regulates natural transformation inbioRxiv : the preprint server for biology · 2023Article
- The RecA-directed recombination pathway of natural transformation initiates at chromosomal replication forks in the pneumococcus.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Competence remodels the pneumococcal cell wall exposing key surface virulence factors that mediate increased host adherence.PLoS biology · 2023Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Competence for genetic transformation is a differentiation program during which exogenous DNA is imported into the cell and integrated into the chromosome. In Streptococcus pneumoniae, competence develops transiently and synchronously in all cells during exponential phase, and is accompanied by a pause in growth. Here, we reveal that this pause is linked to the cell cycle. At least two parallel pathways impair peptidoglycan synthesis in competent cells. Single-cell analyses demonstrate that ComM, a membrane protein induced during competence, inhibits both initiation of cell division and final constriction of the cytokinetic ring. Competence also interferes with the activity of the serine/threonine kinase StkP, the central regulator of pneumococcal cell division. We further present evidence that the ComM-mediated delay in division preserves genomic integrity during transformation. We propose that cell division arrest is programmed in competent pneumococcal cells to ensure that transformation is complete before resumption of cell division, to provide this pathogen with the maximum potential for genetic diversity and adaptation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.