ArticleNature communications2017
Activity-dependent expression of Channelrhodopsin at neuronal synapses.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Investigation of synaptic connectivity in functional in vitro neuronal assemblies.Cell reports methods · 2026Article
- Epigenetic Mechanisms Shaping Spine Regulation: Unveiling the Role of Cytoskeletal Dynamics and Localized Protein Synthesis.Molecular neurobiology · 2025Review
- Compartmentalized dendritic plasticity in the mouse retrosplenial cortex links contextual memories formed close in time.Nature neuroscience · 2025Article
- Distinct spatial distribution of potentiated dendritic spines in encoding- and recall-activated hippocampal neurons.Frontiers in molecular neuroscience · 2025Article
- Inspiring a convergent engineering approach to measure and model the tissue microenvironment.Heliyon · 2024Review
- All-optical presynaptic plasticity induction by photoactivated adenylyl cyclase targeted to axon terminals.Cell reports methods · 2024Article
- Chemogenetic regulation of the TARP-lipid interaction mimics LTP and reversibly modifies behavior.Cell reports · 2023Article
- Flow Cytometry of Synaptoneurosomes (FCS) Reveals Increased Ribosomal S6 and Calcineurin Proteins in Activated Medial Prefrontal Cortex to Nucleus Accumbens Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Editorial: From Whole-Cell to Single Synapse Engrams - Breaking the Code for Memory Formation, Storage and Recall.Frontiers in molecular neuroscience · 2022Article
- Shedding light on learning and memory: optical interrogation of the synaptic circuitry.Current opinion in neurobiology · 2021Review
- Roles and Transcriptional Responses of Inhibitory Neurons in Learning and Memory.Frontiers in molecular neuroscience · 2021Review
- The role of intrinsic excitability in the evolution of memory: Significance in memory allocation, consolidation, and updating.Neurobiology of learning and memory · 2020Review
- Lysosome Dynamic Properties during Neuronal Stem Cell Differentiation Studied by Spatiotemporal Fluctuation Spectroscopy and Organelle Tracking.International journal of molecular sciences · 2020Article
- Neuronal Activity at Synapse Resolution: Reporters and Effectors for Synaptic Neuroscience.Frontiers in molecular neuroscience · 2020Review
- The next generation of approaches to investigate the link between synaptic plasticity and learning.Nature neuroscience · 2019Review
- Photoswitching endogenous glutamate receptors in neural ensembles and single synapses in vivo.Brain stimulationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing evidence points to the importance of dendritic spines in the formation and allocation of memories, and alterations of spine number and physiology are associated to memory and cognitive disorders. Modifications of the activity of subsets of synapses are believed to be crucial for memory establishment. However, the development of a method to directly test this hypothesis, by selectively controlling the activity of potentiated spines, is currently lagging. Here we introduce a hybrid RNA/protein approach to regulate the expression of a light-sensitive membrane channel at activated synapses, enabling selective tagging of potentiated spines following the encoding of a novel context in the hippocampus. This approach can be used to map potentiated synapses in the brain and will make it possible to re-activate the neuron only at previously activated synapses, extending current neuron-tagging technologies in the investigation of memory processes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.